Implication of Cognitive Reserve in Non-pharmacological Intervention Outcomes

Launched by MASARYK UNIVERSITY · Aug 19, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how cognitive reserve (CR)—the brain's ability to use its resources effectively—affects the outcomes of a non-drug treatment for older adults with mild cognitive impairment and dementia with Lewy bodies. The researchers are using a technique called transcranial alternating current stimulation (tACS), which sends gentle electrical currents to the brain to potentially improve memory and cognitive function. They want to see how individual differences, like education level and brain activity, can influence the benefits of this treatment.

To participate in the trial, you would need to be an older adult with intact cognitive abilities or have mild cognitive impairment with Lewy bodies. Key exclusion criteria include having a diagnosis of dementia or any major brain disorders. If you join the study, you can expect to undergo brain stimulation sessions and assessments to measure how your cognition may improve. This research is important because it could lead to better treatment options for people experiencing cognitive decline associated with aging and specific types of dementia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Intact cognitive performance as assessed by cognitive evaluation.
• • 2. Subjects with possible or probable mild cognitive impairment with Lewy bodies (MCI-LB).
• Exclusion Criteria:
• • Presence of dementia as assessed by a cognitive test battery and evaluation of daily activities.
• • Any major psychiatric disorder. History of neurological disease affecting the central nervous system (e.g., tumor, epilepsy, stroke, etc.).
• • Severe or repeated head injury. Non-compensated internal or oncological disease. MRI-incompatible metal in the body (e.g., pacemaker). Left-handedness.