Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease

Launched by ANHUI MEDICAL UNIVERSITY · Aug 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called transcranial alternating current stimulation (tACS) to see how it may help people with early Alzheimer's disease. The goal is to understand both the clinical effects of this treatment and how it works in the brain. Researchers are currently looking for participants aged between 18 and 85 who have been diagnosed with early Alzheimer's disease and have mild cognitive impairment, as shown by specific scoring tests. To be eligible, participants should have been on certain medications for at least three months and should not have any other severe psychiatric issues or serious neurological conditions.

If you or a loved one decides to participate, you can expect to receive tACS treatment, which involves the use of a small device that delivers gentle electrical currents to the scalp. Throughout the trial, participants will undergo assessments to monitor their cognitive abilities and overall health. It's important to note that individuals with certain medical conditions, such as a history of severe head injuries or seizures, cannot take part in this study. This trial aims to explore new ways to support individuals with early Alzheimer's disease and improve their quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Subject diagnosed with early Alzheimer's disease or related diseases according to NIA-AA criteria.
• • 2. Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia.
• • 3. CDR score ≤ 2.
• • 4. Subject under treatment by IAChE for at least 3 months.
• • 5. psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months.
• Exclusion Criteria:
• • 1. CDR \> 2
• • 2. Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
• • 3. History of head injury,stroke,or other neurologic disease.
• • 4. Organic brain defects on T1 or T2 images.
• • 5. History of seizures or unexplained loss of consciousness.
• • 6. Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
• • 7. Family history of medication refractory epilepsy.
• • 8. History of substance abuse within the last 6 months.