The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Launched by INTEGRATIVE SKIN SCIENCE AND RESEARCH · Aug 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different topical treatments, including almond oil and tretinoin (a skin medication), can improve the appearance of facial wrinkles and fine lines in post-menopausal women. The researchers want to see if these treatments can also help with skin hydration and pigmentation issues. The trial is currently looking for participants, specifically women aged 65 to 74 who have visible facial wrinkles and are of certain skin types.

To join the study, participants must meet specific criteria, such as being post-menopausal and having fine lines or wrinkles on their face. However, some individuals will not be eligible, including those who are pregnant or breastfeeding, those with nut allergies, and current smokers. Participants will need to stop using certain skin care products and supplements during the study. If you choose to participate, you can expect to apply the assigned treatments and attend follow-up appointments to assess how well they work.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
• • Individuals with facial fine lines and wrinkles
• Exclusion Criteria:
• • Individuals who are pregnant or breastfeeding
• • Prisoners
• • Adults unable to consent
• • Those with a nut allergy or tocopherol allergy
• • Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
• • Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
• • Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
• • Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
• * Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
• • Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
• • Antioxidant ingredients such as vitamin C or vitamin E.
• • Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
• • Topicals that contain a nut oil or nut extract as part of their ingredient list.