ATG Individualized Dosing Model in URD-PBSCT.

Launched by CHINESE PLA GENERAL HOSPITAL · Aug 26, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to give a medication called anti-thymocyte globulin (ATG) to patients undergoing stem cell transplants from unrelated donors. ATG is used to help prevent complications like severe graft-versus-host disease, but using too much can lead to other serious infections. The trial aims to find out if a personalized dosing plan can help reduce these risks while still being effective. Specifically, the researchers are looking at whether adjusting the amount of ATG given during treatment can lower the chances of reactivating infections like cytomegalovirus (CMV) after the transplant.

To participate in this trial, patients need to be between the ages of 14 and 65, have a certain type of blood cancer, and have an HLA-matched unrelated donor. They should also be in reasonably good health without serious infections or mental health issues. If eligible, participants can expect to receive ATG for four days before their transplant, with doses tailored to their individual needs. This trial is currently recruiting and provides an opportunity for patients to contribute to important research while potentially benefiting from a more personalized treatment approach.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with malignant hematological tumors who have indications for allogeneic hematopoietic stem cell transplantation.
• • 2. HLA-matched unrelated donor
• • 3. Patient age ≥14 years old and ≤65 years old
• • 4. ALT and AST ≤ 2.5 times the upper limit of normal values, bilirubin ≤ 2 times the upper limit of normal values
• • 5. Creatinine ≤ high limit of normal value
• • 6. No uncontrollable infection or serious mental illness
• • 7. Physical strength score is 0-2 (ECOG)
• • 8. Sign the informed consent form
• Exclusion Criteria:
• • 1. Unrelated donor who is not HLA matched
• • 2. No indication for allogeneic hematopoietic stem cell transplantation
• • 3. Patient age \<14 years old or \>65 years old
• • 4. The donor or recipient are pregnant
• • 5. Suffering from mental illness or other conditions and being unable to proceed as planned