USPIO Enhanced MR Imaging in CNS Tumours (UMIC)

Launched by NORTHERN CARE ALLIANCE NHS FOUNDATION TRUST · Aug 22, 2024

Keywords

ClinConnect Summary

The USPIO Enhanced MR Imaging in CNS Tumours (UMIC) trial is exploring a new way to better understand certain brain tumors, specifically vestibular schwannomas and low-grade gliomas. The study aims to see if a special imaging technique using a substance called ferumoxytol can accurately measure the number of inflammatory cells, known as macrophages, within these tumors. These cells can play a big role in how tumors grow and respond to treatment. By using advanced MRI scans before and after the injection of ferumoxytol, researchers will study how well this method works to identify and monitor inflammation in the tumors.

To be part of this study, participants need to be at least 16 years old and have a confirmed diagnosis of one of the targeted brain tumors. They should also be able to stay still for about an hour during the MRI scans. However, people with certain health conditions, previous treatments, or those who are pregnant or breastfeeding cannot participate. If eligible, participants will receive an injection of ferumoxytol and undergo several MRI scans to gather important information about their tumors. This research could help improve how doctors monitor and treat brain tumors in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Be at least 16 years old
• • Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
• • Be able to lie still for up to 1 hour comfortably
• • Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.
• Exclusion Criteria:
• • Life expectancy less than 1 year
• • Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
• • Females who are pregnant/ breastfeeding
• • Patients with an eGFR \< 30ml/min
• • Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
• • Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
• • Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia) contraindications to MR scanning
• • Patients with a history of allergic reaction to iron or dextran
• • Patients with a history of allergic reaction to gadolinium contrast agents, asthma or renal problems
• • Patients who are unable to adequately understand verbal explanations or written information given in English.