Noninvasive Ventilation Breathing Test Guiding Weaning in Patients With Acute Hypoxic Respiratory Failure

Launched by WEST CHINA HOSPITAL · Aug 23, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help patients with acute hypoxic respiratory failure, a condition where the body does not get enough oxygen. The researchers want to find out the best timing to switch from invasive mechanical ventilation (where a tube is placed in the throat to help with breathing) to non-invasive ventilation (where a mask is used). The goal is to help patients breathe better while reducing the time they need to spend on a breathing machine and lowering the risk of complications.

To be eligible for this study, participants need to be adults aged 18 to 80 who have been admitted to the intensive care unit with acute hypoxic respiratory failure and have been on a breathing tube for more than a day. Patients who have serious health issues, like severe heart or lung problems, or those who cannot wear a mask due to injuries or other reasons, will not be included. If someone participates, they can expect to take part in breathing tests that will help determine the right time to switch to non-invasive ventilation, aiming for a safer and quicker recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients who have been admitted to the intensive care unit (ICU) with Acute Hypoxic Respiratory Failure. Oxygenation index less than 300mmHg, have undergone tracheal intubation, and are anticipated received invasive mechanical ventilation for more than 24 hours.
• Exclusion Criteria:
• • • Age over 80 years,
• • Pregnancy,
• • Consciousness disorders or intracranial hypertension caused by various reasons,
• • Neuromuscular disorders,
• • Severe cardiac dysfunction (New York Heart Association Class III or IV, acute coronary syndrome or persistent ventricular tachycardia),
• • Cardiogenic shock or after major cardiac surgery,
• • Severe liver and kidney failure,
• • Severe malnutrition,
• • Injury to the upper airway or nose and face, making it impossible to wear a nose (face) mask,
• • Severe agitation, Severe agitation, expected to be unable to cooperate with non-invasive mechanical ventilation.