Satiety and Alcohol Challenge

Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Aug 26, 2024

Keywords

ClinConnect Summary

This clinical trial, called the "Satiety and Alcohol Challenge," aims to understand how feelings of fullness (or satiety) affect people’s responses to drinking alcohol. Researchers will conduct this study in a lab setting where participants will take either a dietary supplement that includes fiber and green tea or a placebo (a fake treatment that looks the same but has no active ingredients). After taking these products, participants will be given alcohol to see how their body reacts.

To be eligible for this study, participants must be between 21 and 45 years old, meet specific guidelines for at-risk drinking, and have a body mass index (BMI) between 21 and 30. They should also be willing to participate in laboratory sessions that involve blood tests and alcohol consumption. However, individuals with a history of severe alcohol use disorder, current alcohol treatment, certain medical conditions, or those who are pregnant or nursing cannot participate. If you join this study, you can expect to learn more about how your body processes alcohol while researchers gather important information that could help better understand drinking behaviors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 21-45
• • Meeting NIAAA criteria for current at-risk drinking (i.e., \>7/14 drinks in one week for women/men, with at least one episodes of 4+/5+ drinks in the past 30 days)
• • Willingness to complete laboratory sessions involving blood draws and alcohol administration
• • Ability to communicate and read in English
• • Body mass index (BMI) of 21 - 30 kg/m\^2
• Exclusion Criteria:
• • Meets past-year criteria for severe Alcohol Use Disorder (\>7 of 11 symptoms endorsed) or AUDIT score of 20+
• • Meeting past-year criteria for a substance use disorder (with the exception of alcohol, tobacco or mild cannabis use disorder)
• • Current engagement in alcohol treatments, or currently engaged in intentional efforts to quit alcohol use
• • Current use of weight control medications
• • Lifetime diagnosis of severe mental illness (including schizophrenia and bipolar disorder)
• • History of suicide attempt, or psychiatric hospitalization in the last 6 months
• • History of diabetes
• • Medical conditions or medications for which alcohol is contraindicated
• • Pregnant, nursing, or trying to become pregnant
• • Plans to travel during the duration of study participation