Osteosarcopenia in Axial Spondyloarthritis

Launched by ANKARA UNIVERSITY · Aug 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called osteosarcopenia in patients with axial spondyloarthritis (AxSpA), which is a type of chronic inflammation affecting the spine and joints. Osteosarcopenia refers to having both weak bones (osteoporosis) and muscle loss (sarcopenia). The researchers want to find out how common osteosarcopenia is among people with AxSpA and how it relates to factors like age and health status. They will compare patients with AxSpA to a healthy group of similar ages and genders to see if osteosarcopenia occurs more often in those with AxSpA.

To participate in the study, you need to be between 18 and 65 years old and have a confirmed diagnosis of AxSpA, either ankylosing spondylitis or non-radiographic spondyloarthritis. Participants must also be in good overall health without certain medical conditions or medications that could affect the study results. If you join, you can expect to undergo some assessments to evaluate your bone and muscle health. This study aims to improve understanding of how osteosarcopenia affects people with AxSpA, which could help guide future treatment and care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patient group:
• • Participants with a diagnosis of AxSpA: Participants with diagnosis of Ankylosing Spondylitis according to the modified New York criteria and participants with diagnosis of non-radiographic Spondyloarthritis (SpA) according to the Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria.
• • Aged 18-65 years
• • Who gave consent to participate in the study
• Healthy control group:
• • Age- and gender-matched healthy participants (age 18-65)
• • Who gave consent to participate in the study
• Exclusion Criteria:
• • 1. Systemic high-dose steroid use (\>5mg/day of prednisone for more than 3 months)
• • 2. Possible other causes of secondary sarcopenia (uncontrolled diabetes, chronic heart failure, thyroid/parathyroid disease, chronic renal failure, chronic liver failure)
• • 3. Hand-related disorders/diseases that could affect the healthy assessment of grip strength
• • 4. Use of any medication that could potentially affect the bone metabolism (bisphosphonates, teriparatide, anticonvulsants, heparin, and anticoagulants)
• • 5. Psoriasis, inflammatory bowel disease
• • 6. Infection in the thigh area where ultrasonographic evaluation will be performed
• • 7. Body weight over 100 kg (contraindication to be positioned in the BMD device)
• • 8. Presence of malnutrition (individuals scoring 11 or below on the Mini Nutritional Assessment-Short Form (MNA))