PRospective Observation on CErebral microvaScular Structure and Function

Launched by BEIJING TIANTAN HOSPITAL · Aug 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how small blood vessels in the brain work and how they might be affected by various health factors. Researchers want to understand how common problems with these small vessels are in people living in a community in China, especially as they relate to conditions like memory issues, heart disease, and stroke. They will use advanced imaging techniques, which are like special pictures of the blood vessels, to gather information about these conditions.

To take part in this study, you need to be between 50 and 75 years old and a resident of Beijing who can be followed for a long time. You should be generally healthy, without severe disabilities or serious brain conditions. If you join, you will undergo some imaging tests and provide information about your health. This study aims to find out more about brain health and how it connects to overall well-being, which could help improve care for older adults in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Community-dwelling adults aged 50-75 years;
• • 2. Registered Beijing household residents or residents who can be followed up stably in their own communities for a long period;
• • 3. Subjects with written informed consents.
• Exclusion Criteria:
• • 1. Residents with moderate to severe disabilities (MRS ≥3), mental illness, stroke, dementia, and other serious neurological disorders (e.g., encephalitis, Parkinson's disease, epilepsy, brain tumors, and rare genetic diseases of the nervous system);
• • 2. Life expectancy of ≤4 years due to serious diseases such as end-stage cancer;
• • 3. Contraindications to magnetic resonance imaging such as implanted devices (e.g., pacemakers, defibrillators, and others);
• • 4. Residents who are participating in other studies.