Normalizing Antibody Detection in First-void Urine

Launched by UNIVERSITEIT ANTWERPEN · Aug 30, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well the body responds to HPV vaccines, specifically by measuring certain antibodies in the first urine of the day. The researchers want to find reliable ways to check how effective the vaccine is and see if there are any changes in these antibodies over time in different groups of people.

To participate in this study, you need to have received one of the HPV vaccines, such as Cervarix or Gardasil, and be able to show proof of your vaccination. You should also be willing to let the researchers contact your doctor for information about your vaccination history and any cervical cancer screenings you may have had. However, if you are currently pregnant, have certain health issues, or are involved in another clinical trial, you won't be eligible to join. If you take part, you can expect to provide urine samples and answer questions about your health, helping researchers understand more about vaccine-induced immunity against HPV.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Vaccinated with either the Cervarix, Gardasil or Gardasil9 HPV-vaccine and able to present vaccination booklet or another official document proving this.
• • Able to understand the information brochure and what the study is about.
• • Willing to give informed consent to contact his/her general practitioner and/or gynecologist to access details on their HPV vaccination schedule and, in case a woman within the screening population, cervical cancer screening results (smears, HPV tests, colposcopy, biopsy).
• Exclusion Criteria:
• • Participating in another clinical trial at the same time of participating in this study.
• • Women that underwent hysterectomy or were treated for cervical (pre)cancer lesions within the six months prior to study enrolment.
• • Pregnant women.
• • Being positive for Human Immunodeficiency Virus (HIV), Hepatitis B or Hepatitis C.
• • Having a history or current evidence of any condition or abnormality that might confound the results of the study or is not in the best interest of the individual to participate, in the opinion of the investigator.