Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

Launched by UNIVERSITY OF KANSAS MEDICAL CENTER · Aug 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called lidocaine to help manage headaches that occur after a type of brain bleed known as non-traumatic subarachnoid hemorrhage. The researchers want to find out if giving lidocaine through an IV (a small tube in the vein) can significantly reduce headache pain and if this treatment is safe for patients. They will also look at how often blood vessel narrowing (called vasospasm) occurs in patients as part of their routine care.

To participate in this study, patients need to be 18 years or older and have a specific level of awareness and ability to communicate their pain levels. They should also have a diagnosis of non-traumatic subarachnoid hemorrhage. Participants will receive the lidocaine treatment and share their pain scores every two hours while they are awake for up to seven days. It’s important for potential participants to know that people with certain conditions, like traumatic subarachnoid hemorrhage or serious heart problems, will not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients \> 18 years;
• • Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness);
• • Can communicate numeric pain scores;
• • Are diagnosed with non-traumatic subarachnoid hemorrhage
• Exclusion Criteria:
• • The patient is diagnosed with traumatic subarachnoid hemorrhage;
• • If the patient is \< 18 years of age;
• • If numeric pain scores could not be captured for \> 3 days of hospitalization;
• • If the patient had a prior aneurysm;
• • Chronic pain not associated with non-traumatic subarachnoid hemorrhage diagnosis;
• • A disability before the stroke (\> 2 on modified Rankin Scale score);
• • A Hunt and Hess score \> 3;
• • Contraindications to lidocaine (significant cardiac disease, arrhythmia, seizures, previous allergic reaction to lidocaine