Management of Anemia in Patients with EndocaRditis Infectious Candidates for Cardiac Surgery: the AMERICA Study
Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Sep 2, 2024
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
The AMERICA Study is a clinical trial that aims to improve the management of anemia in patients with infective endocarditis (EI) who are preparing for heart surgery. Infective endocarditis is a serious infection that affects the heart and often leads to anemia, a condition where the body doesn’t have enough healthy red blood cells. This study will explore various ways to treat anemia beyond just blood transfusions, including correcting vitamin and iron deficiencies and using medications that help the body produce more red blood cells.
To participate in this trial, individuals must be at least 18 years old and diagnosed with infective endocarditis, making them candidates for elective cardiac surgery. Participants will need to provide written consent and may undergo various assessments to help manage their anemia as part of their overall treatment plan. This study is not yet recruiting participants, but it aims to help improve care for patients with this serious condition.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria: Patients with endocarditis who are candidates for elective surgery; Male and female patients aged \> 18 years; Patients who have given written consent to participate in the study and to have their clinical data processed for the purposes of the study.
- • Exclusion Criteria: Age \< 18 years; Patients with hypersensitivity (bronchial asthma, urticaria, allergic phenomena) to preparations of intravenous iron, folic acid, vitamin B12, erythropoietin; Patients who have not given written consent to participate in the study and who have specifically refused the use of their clinical data for the purposes of the study; Patients participating in other investigational trials; Any other clinical condition that in the opinion of the investigator would make the patient unsuitable for the study
About Fondazione Policlinico Universitario Agostino Gemelli Irccs
Fondazione Policlinico Universitario Agostino Gemelli IRCCS is a leading research and healthcare institution based in Rome, Italy, renowned for its commitment to advancing medical science and improving patient care. As a prominent academic medical center affiliated with the Catholic University of the Sacred Heart, it integrates clinical practice, education, and research, fostering innovation in various fields of medicine. The foundation conducts a wide range of clinical trials aimed at developing new therapies and enhancing treatment protocols, with a focus on translational research that bridges the gap between laboratory discoveries and patient care. Its multidisciplinary approach and dedication to high ethical standards position it as a key player in the landscape of clinical research and healthcare improvement in Italy and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Roma, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported