A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke

Launched by NANFANG HOSPITAL, SOUTHERN MEDICAL UNIVERSITY · Sep 3, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how changes in our body's proteins, gut bacteria, and small molecules can help predict the early outcomes and chances of stroke recurrence in adults who have experienced an acute ischemic stroke (AIS). By analyzing samples from patients and using advanced computer models, researchers aim to identify key factors that could signal how well a patient will recover and if they might have another stroke in the future. This information could lead to better prevention strategies and treatments for stroke patients.

To participate in this trial, individuals must be between 18 and 75 years old and have had a stroke within the last week. They also need to provide consent and share some medical history and biological samples, such as blood or stool. However, people with certain serious health conditions, recent strokes, or difficulties providing samples may not be eligible. Participants can expect to contribute to important research that could improve stroke care while being closely monitored throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Meet the diagnostic criteria of AIS according to the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018
• • 2. Aged 18 to 75 years old
• • 3. Stroke within 7 days of onset
• • 4. Sign informed consent, provide relevant medical history information and provide biological specimens
• Exclusion Criteria:
• • 1. Severe impairment of consciousness (awareness score of NIHSS\>1)
• • 2. History of stroke within 12 months
• • 3. Severe systemic disease including malignancy
• • 4. ALT or AST\> 2 times the upper limit of normal or severe liver disease
• • 5. creatinine \> 1.5 times the upper limit of normal or severe kidney disease
• • 6. History of long-term drinking, drug use, and chemical poisoning (e.g., pesticide poisoning); Note: Long-term alcohol consumption, usually more than 5 years, over 40 g/day of alcohol for men and 20 g/day for women, or a history of heavy alcohol consumption within 2 weeks, over 80 g/day of alcohol
• • 7. History of intestinal tumors, irritable bowel syndrome or inflammatory bowel disease or confirmed in the hospital
• • 8. Unable to collect a stool specimen within 4 days of admission
• • 9. Assessed to be unsuitable for participation in this study by the investigator