Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft

Launched by UNIVERSITÀ VITA-SALUTE SAN RAFFAELE · Sep 2, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how effective two different types of tendon grafts are for patients over 40 years old who have had surgery to reconstruct a torn ACL (an important ligament in the knee). The study aims to compare the success rates of using allograft tendons (which come from a donor) versus autograft tendons (which come from the patient’s own body) in preventing graft failure, which means whether the new tendon holds up over time. Researchers want to see if there are differences in how well patients recover and function with each type of graft after at least two years.

To participate in this study, individuals must be 40 years old or older and should have had primary ACL reconstruction using either type of tendon. They also need to be able to give their consent to join the trial. However, some people will not be eligible, such as those with multiple ligament injuries or significant knee issues. Participants can expect to be followed for two years to assess their recovery and the performance of the grafts. This study is important because it will help doctors understand which type of graft works better for older patients, potentially leading to improved treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant is willing and able to give informed consent for participation in the study.
• • Male and female patients of fertile age can be recruited
• • Patients aged 40 years old and above, and 2 years minimum of follow-up
• • Patients that underwent primary ACL reconstruction with allograft an autograft tendons
• Exclusion Criteria:
• • Multiligamentous lesion
• • Meniscal tear leading to subtotal or total meniscectomy or meniscal graft
• • Indication for major cartilage restoration or resurfacing
• • Ipsilateral knee fractures
• • History of ligament injury
• • Concomitant extracapsular procedures
• • Ipsilateral or contralateral knee surgeries