Quantifying New Heart Muscle Cells

Launched by WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY · Sep 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the heart creates new muscle cells in babies with certain types of heart problems, like Tetralogy of Fallot with Pulmonary Stenosis or heart failure. Usually, the heart’s ability to repair itself by making new muscle cells decreases soon after birth, but researchers don’t know exactly when this happens or how heart disease might affect it. By looking at heart tissue removed during planned heart surgeries, the study aims to learn more about how well young hearts can regenerate and whether this ability might be boosted to help treat heart failure in the future.

Babies between 1 month and 1 year old who are scheduled for certain heart surgeries that involve removing a small piece of heart muscle may be eligible to join. If the surgery is expected to include this tissue removal, the doctors can use that tissue for research without adding extra procedures. Families can expect that the study will use the tissue that would otherwise be removed during surgery, so no extra surgery or risk is involved. This study is currently looking for participants and is focused on helping improve treatments for young children with serious heart conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients at 30 days of age to 1 year of age undergoing scheduled elective cardiac surgery will be eligible for study inclusion.
• • The investigators will recruit patients at 30 days of age to 1 year of age with those types of heart disease whose surgical approach has a high probability of myocardial resection.
• • Diagnosis of ToF/PS or other types of heart disease that have a high likelihood of requiring surgery that involves routine resection of myocardium that becomes available for research
• Exclusion Criteria:
• • Patients with low chance of having resection of myocardium as part of their surgical care.