Nitrate Mouth Rinse and the Oral Microbiome

Launched by DALHOUSIE UNIVERSITY · Sep 5, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how using a mouth rinse rich in nitrates might change the bacteria in our mouths, known as the oral microbiome. Participants will be divided into two groups: one group will use a regular water mouth rinse, while the other group will use the nitrate mouth rinse, both once a day for two weeks. Researchers want to see if there are any differences in the bacteria in the mouth, as well as changes in blood pressure and levels of nitric oxide in saliva.

To join the study, you need to be between 18 and 40 years old and in good health, with no serious medical conditions. If you have mild conditions like asthma or type 1 diabetes, you may still be eligible. However, if you're under 18, have uncontrolled health issues, or are currently taking certain medications or have specific oral health problems, you would not qualify. Participants can expect to maintain their usual oral hygiene habits while using the mouth rinse, and they will help researchers learn more about how the mouth can impact overall health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • You are between the ages of 18 and 40. Have no uncontrolled systemic diseases.
• Participants with mild chronic conditions such as:
• • Asthma
• • Type 1 Diabetes Mellitus
• Exclusion Criteria:
• • You are under the age of 18.
• • You have uncontrolled systemic diseases, or acute infections.
• • You are taking prescription, antibiotics, probiotics, or antimicrobial mouthrinses.
• • You have a documented true allergy (i.e Hives, Swelling of lips/throat) Soy, Nuts, Seeds, Dairy, Egg products, Fish/Shellfish or Wheat.
• * The presence of acute or chronic oral conditions including:
• • Herpes Simplex Virus (recent cold sores)
• • Stomatitis
• • Oral Lichen Planus
• • Angular Cheilitis
• • Candidiasis
• • Necrotizing Gingival Diseases
• • Other inflammatory or infectious pathologies
• • Active dental caries "cavities"
• • Any other periodontal diagnosis other than 'Healthy Periodontium' or localized gingivitis