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Search / Trial NCT06589947

StOPping Hypertension and imprOving Children's Lives After KidnEy TranSplantation

Launched by HANNOVER MEDICAL SCHOOL · Sep 6, 2024

Trial Information

Current as of July 24, 2025

Not yet recruiting

Keywords

Left Ventricular Mass Pediatric Kidney Transplantation

ClinConnect Summary

The StOPping Hypertension and improving Children's Lives After Kidney Transplantation trial is designed to study how managing blood pressure (BP) can improve heart health in children who have received kidney transplants. This is important because many children after a transplant experience high blood pressure, which can lead to serious heart problems. The trial will involve 500 children who had their kidney transplant more than a year ago and are dealing with high blood pressure. Participants will be divided into two groups: one group will receive more intensive blood pressure management, aiming for a lower target, while the other group will follow standard care.

To join the study, children must have had a kidney transplant at least 12 months ago and have high blood pressure. However, those with certain heart conditions or recent treatment for transplant rejection will not be eligible. Throughout the trial, participants will have their blood pressure monitored closely, and their heart health will be assessed over two years. The findings from this study could help set new guidelines for blood pressure treatment in children after kidney transplants, potentially improving their long-term health and quality of life.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Kidney transplantation \>12 months ago
  • Arterial hypertension
  • Exclusion Criteria:
  • Cardiac malformation
  • Treatment for a rejection episode within three months prior to inclusion

About Hannover Medical School

Hannover Medical School (Medizinische Hochschule Hannover, MHH) is a leading academic medical institution in Germany, renowned for its commitment to innovative research and high-quality clinical care. Established in 1965, MHH specializes in a wide range of medical disciplines, with a strong focus on transplantation medicine, regenerative medicine, and personalized healthcare. The institution actively participates in clinical trials to advance medical knowledge and develop cutting-edge therapies, leveraging its state-of-the-art facilities and collaborative environment. With a dedicated team of researchers, clinicians, and support staff, Hannover Medical School aims to translate scientific findings into practical applications that improve patient outcomes and enhance the overall quality of healthcare.

Locations

Patients applied

0 patients applied

Trial Officials

Anette Melk, MD PhD

Principal Investigator

Hannover Medical School

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported