Establishment of Multiparametric Prediction Models for Moderate to SevereThyroid Associated Ophthalmopathy

Launched by SHANGHAI CHANGZHENG HOSPITAL · Sep 5, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on improving the diagnosis and treatment of moderate to severe thyroid-associated ophthalmopathy (TAO), a condition where the eyes can become swollen and painful due to an autoimmune response related to thyroid disease. The goal of the study is to find new ways to diagnose TAO and create a reliable prediction model that helps doctors decide the best treatment for patients based on the severity of their condition. This is important because severe TAO can lead to serious vision problems, affecting daily life and even potentially causing blindness.

To participate in this study, individuals must be diagnosed with moderate to severe TAO at the hospital after a specific date and score a certain level of disease severity on a scale used by doctors. Unfortunately, those who have had significant recent vision issues or certain other health conditions may not be eligible. Although the trial is not yet recruiting participants, it aims to gather important information that could lead to better care for patients with this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • According to the Bartley criteria，diagnosed TAO at our hospital after 2024/8/31
• • Moderate to severe patients defined by EUGOGO
• • CAS ≥3 (on the 7-item scale) for the study eye
• Exclusion Criteria:
• • Anticipated need for intervention due to sight-threatening complications or other significant and acute deterioration in vision
• • History of systemic (eg, oral or IV) steroid use with a cumulative dose equivalent to \>1 g of methylprednisolone for the treatment of TAO.
• • Any major illness/condition or evidence of an unstable clinical condition that, in the investigator\'s judgment, will substantially increase the risk to the participant, or confound the interpretation of safety assessments, if they were to participate in the study
• • Any other condition that, in the opinion of the investigator, would impair the ability of the participant to comply with the study procedures or impair the ability to interpret data from the participant\'s participation in the study
• • Pregnant or lactating
• • Any other condition that,would impair the ability of the participant to undergo orbital MRI
• • Incomplete information