The STatus Epilepticus Prognosis Study

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Sep 8, 2024

Keywords

ClinConnect Summary

The STatus Epilepticus Prognosis Study is a research trial designed to help understand and improve the outcomes for patients experiencing Status Epilepticus (SE), a serious condition characterized by prolonged seizures. The study has three main parts: first, researchers will look for specific markers in the blood that can help predict how well patients will recover after SE; second, they will assess the cognitive abilities of survivors up to a year after their treatment using a special testing platform; and third, they will use brain scans to explore any structural changes in the brains of patients who have had SE. This information is important because it can provide insights into both immediate and long-term effects of SE on patients' health.

To participate in this study, individuals must be between 18 and 80 years old and have experienced SE while in the intensive care unit (ICU). They should not have other serious brain conditions that could affect their thinking abilities, such as dementia or Parkinson's disease. The study is currently looking for participants, and those who join can expect to undergo blood tests, cognitive assessments, and brain scans at specific times during their recovery. This research could lead to better care and support for individuals affected by Status Epilepticus in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 to 80 years of age
• • SE requiring admission to critical care
• • Developed SE while in ICU
• • No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
• • Absence of devastating neurologic injury (cardiac arrest, stroke, traumatic brain injury)
• In addition, for non-SE epilepsy controls for Creyos task:
• • People with epilepsy
• • No history of status epilepticus
• • Patient has not stereotaxic EEG monitoring
• • English speaking
• • No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
• In addition, for follow up MRI purposes only:
• • Diagnosed with refractory status epilepticus while in ICU
• • No MRI contraindications (metal in body, pacemakers, etc.)
• Inclusion Criteria Healthy Control Population for MRI imaging:
• • No history of a neurologic condition that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease)
• • No MRI contraindications (metal in body, pacemakers, etc.)
• Exclusion Criteria:
• • patients not meeting inclusion criteria
• • acute brain injury or brain tumour as immediate cause of status epilepticus