HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML

Launched by MASONIC CANCER CENTER, UNIVERSITY OF MINNESOTA · Sep 10, 2024

Keywords

ClinConnect Summary

This clinical trial, titled HM2023-05, is studying a new treatment called GTB-3650 for adults aged 18 and older who have certain types of blood cancer, specifically Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS). This trial is designed for patients whose cancer has not responded to standard treatments and who are not candidates for more aggressive therapies like stem cell transplants. GTB-3650 aims to help the body’s immune system better target and fight the cancer by activating specific immune cells.

To be eligible for this trial, participants must have a certain level of immune cells in their blood and meet other health criteria. They should not be pregnant or breastfeeding, and they need to be able to stay close to the study center during the initial treatment phase. Those who join the study can expect to receive the new treatment and will be monitored closely for any side effects. It's important to know that this is an early-stage trial, so the main goal is to find a safe dose and learn how well GTB-3650 works against these challenging blood cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of a high risk myelodysplastic syndromes (MDS), treatment related MDS, OR relapsed/refractory acute myelogenous leukemia (AML).
• • Absolute lymphocyte count (ALC) ≥ 200 cells/µL OR absolute circulating CD56+/CD3- NK cell count \>25 cells/µL within the 14 days prior to Cycle 1 Day 1.
• • Peripheral blasts ≤20,000 at the time of treatment start. Hydroxyurea may be used up to Day 1 of the 1st cycle to achieve this threshold and continued for the 1st two weeks of Cycle 1 to maintain it.
• • Karnofsky performance status ≥ 70%
• • Adequate organ function within 14 days (30 days for cardiac) of Cycle 1 Day 1
• • Sexually active persons of childbearing potential or persons with partners of childbearing potential must agree to use a highly effective form of contraception during study treatment and for at least 4 months after the last dose of GTB-3650. Non-childbearing is defined as \>1 year postmenopausal or surgically sterilized.
• • -For the Dose Finding Component Only: Must agree to stay within a 60- minute drive of the Study Center through the Cycle 1 Day 29 visit (end of the Dose Limiting Toxicity period).
• • Provides voluntary written consent prior to the performance of any research related activity.
• • Pulmonary: room air 0 2 saturation at ≥ 95%
• Exclusion Criteria:
• • Pregnant or breast-feeding. The effect of GTB-3650 TriKE on the fetus is unknown. Persons of childbearing potential must have a negative serum or urine test within 7 days prior to Cycle 1 Day 1 to rule out pregnancy.
• • A candidate for hematopoietic stem cell transplant (HSCT) or newly relapsed after HSCT (e.g. no post-HSCT therapy given).
• • Bi-phenotypic acute leukemia or mixed lineage leukemia.
• • Acute promyelocytic leukemia (APL).
• • No anticancer therapy within 14 days of Cycle 1 Day 1; any AEs from therapy given prior must have resolved to Grade 1 or baseline
• • New or progressive pulmonary infiltrates on screening chest x-ray or chest CT scan unless cleared for study by Pulmonary. Infiltrates attributed to infection must be stable/improving with associated clinical improvement after 1 week of appropriate therapy (4 weeks for presumed or documented fungal infections).
• • Active systemic infection requiring parenteral antibiotic therapy. Any prior systemic infections must have resolved following optimal therapy.
• • Known history of HIV.
• • Active Hepatitis B or Hepatitis C (virus detectable by PCR) - chronic asymptomatic viral hepatitis is allowed.
• • Positive test results from chronic hepatitis B infection (defined as positive HBsAg serology) and/or positive test results for hepatitis C (HCV antibody serology test).
• • Prior malignancy except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer currently in complete remission, or any other cancer from which the patient has been disease-free for 1 year
• • Active central nervous system (CNS) malignancy or symptoms of CNS spread or administration of IT chemotherapy within 14 days prior to Day 1.
• • Extramedullary disease causing symptoms and/or involving the CNS or spinal canal - asymptomatic extramedullary disease outside the CNS and spinal canal is eligible provided the marrow has measurable disease.
• • Known autoimmune disease requiring active treatment with steroids or other immunosuppressive medications within 14 days before Cycle 1 Day. Inhaled or topical steroids, and adrenal replacement steroid doses ≤ 10 mg daily prednisone equivalent, are permitted in the absence of active autoimmune disease.
• • Persons with a condition requiring systemic treatment with steroids (\> 10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days before Cycle 1 Day 1.
• • The potential risk of QT/QTc prolongation is unknown in humans receiving
• TriKE therefore either of the following is an exclusion criteria:
• • QTc interval \> 480 msec at screening
• • A family history of long QT syndrome
• • Psychiatric illness/social situations that, in the judgement of the enrolling Investigator, would limit compliance with study requirements.
• • Other illness or a medical issue that, in the judgement of the enrolling Investigator, would exclude the patient from participating in this study.