Follow-up Study of Individuals with Autoantibodies Against Ro/SSA and La/SSB

Launched by KAROLINSKA INSTITUTET · Sep 10, 2024

Keywords

ClinConnect Summary

This clinical trial is studying people who have tested positive for certain autoantibodies called Ro/SSA and La/SSB. These autoantibodies can sometimes lead to autoimmune diseases, where the body mistakenly attacks its own tissues. The researchers want to understand how these autoantibodies can change over time and what early signs or environmental factors might indicate that a person is at risk of developing a related disease.

If you are between the ages of 65 and 74 and have tested positive for Ro/SSA or La/SSB, you may be eligible to participate in the study. Those who do not have these autoantibodies or any rheumatologic disease can also take part as a comparison group. Participants will be monitored over time, and they can expect to share information about their health and complete questionnaires. It's important to note that individuals under 18, those who cannot provide consent, or anyone currently facing severe health issues are not eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• To be included in the risk group, the following criteria must be met:
• • - At least one instance of testing positive for Ro/SSA or La/SSB, regardless of the method used.
• To be included in the control group, the individual must:
• • - Have no rheumatologic disease and no autoantibodies against Ro/SSA or La/SSB.
• Exclusion Criteria:
• • 1. Below 18 years of age
• • 2. Inability to consent to their own participation
• • 3. Ongoing infection or severe illness where the study physician deems participation in the study not to be in the individuals best interest
• • 4. Inability to read and understand Swedish, and therefore unable to complete the forms and questionnaires included in the project