Effects of Combined 40 Hz Audio-visual Stimulation and Cognitive Games on Alzheimer's Disease

Launched by ISTANBUL MEDIPOL UNIVERSITY HOSPITAL · Sep 11, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a special digital application designed to help people with Alzheimer’s Disease (AD) by using sound and light stimulation along with cognitive games. The goal is to see if this combination can improve brain function and slow down the progression of the disease. Researchers will compare the results from patients who use the application for three months with those who do not and with healthy older adults. They will assess changes in cognitive abilities through regular check-ups and brain activity recordings.

To participate, individuals must be aged 60 to 86 and have a diagnosis of Alzheimer’s Disease with some difficulty in daily activities. They should also be stable on their current medications. However, those with other types of dementia or certain mental health issues won’t be eligible. Throughout the trial, participants will use the application at home, and their progress will be tracked with monthly assessments. By the end of the study, researchers hope to have developed a useful tool that can help monitor and potentially improve cognitive health in Alzheimer’s patients.

Gender

ALL

Eligibility criteria

• Inclusion and Exclusion Criteria for Alzheimer Patients:
• Inclusion Criteria:
• • Diagnosed with AD according to DSM-IV and NINCDS-ADRDA criteria,
• • Impaired activities of daily living,
• • Having a CDR score of 1-2 and an SMMT score of 15-26,
• • Stable use of psychoactive medications, including acetylcholinesterase inhibitors or other medications that enhance cognitive functions,
• • Individuals aged 60-86 with at least 5 years of education.
• Exclusion Criteria:
• • Having frontotemporal dementia, vascular dementia, Lewy body dementia or other types of dementia,
• • Parkinsonism, clinical depression, other mental disorders, epilepsy, drug addiction, alcohol addiction, and traumatic brain injury
• Inclusion and Exclusion Criteria of Healthy Older Adults:
• Inclusion criteria:
• • Between the ages of 60-86
• • Without any neurological abnormalities or general cognitive impairment (MMSE above 25),
• • Not diagnosed with a neurological and/or psychiatric disease,
• • Not using neurological and/or psychiatric medication
• • Exclusion criteria
• • Having clinical signs of cognitive impairment, such as mild cognitive impairment, Alzheimer disease, Parkinson disease, Lewy body dementia, frontotemporal dementia, etc.
• • Epilepsy, alcohol and/or drug addiction, use of medications that affect cognitive functions, and traumatic brain injury