Prospective Observational Cohort Study of Moderate Aortic Valve Disease

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Sep 11, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how moderate aortic valve diseases, specifically aortic stenosis (narrowing of the valve) and aortic regurgitation (leaking of the valve), progress over time. Researchers want to understand how different factors, like tests and therapies, might affect the worsening of these conditions. They hope that by gathering this information, they can better predict how these diseases will develop and how treatments might help.

To participate in this study, you need to be at least 18 years old and have moderate aortic valve disease as shown by heart imaging tests. However, if you have severe valve problems, are planning heart surgery soon, or have certain other serious health issues, you may not qualify. If you join the study, you can expect to undergo various tests and follow-ups to help researchers gather important information about your condition. It's an opportunity to contribute to understanding and potentially improving treatment for aortic valve diseases.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • At least 18 years old
• • Be willing and able to provide informed consent to participate in the study
• • Patient has moderate aortic valve diseases with echocardiographically derived criteria
• Exclusion Criteria:
• • Severe aortic valve diseases with echocardiographically derived criteria or planned cardiac surgery or likely need for surgery within 6 months
• • Patients who have undergone elective transfemoral transcatheter aortic valve replacement
• • Life expectancy is less than 12 months due to non-heart disease (such as cancer, chronic liver disease, chronic kidney disease, or chronic end-stage lung disease, etc.)
• • Severe dementia (cannot sign research informed consent, cannot take care of themselves or complete the study visit)
• • Acute pulmonary oedema or cardiogenic shock
• • The investigator believes that the patient is not suitable to participate in the study or complete the follow-up prescribed by the protocol from other medical, social and psychological aspects
• • The patient is currently participating in another randomized study