Persistent Organic Pollutants and Mechanical Discharge: Limiting the Impact of Bariatric Surgery Through Personalized Adapted Physical Activity

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NICE · Sep 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how specific types of physical activity can help patients who are scheduled for bariatric surgery, a procedure to help with severe obesity. While bariatric surgery can lead to significant weight loss and improve health, it can also cause some negative effects on the body, such as the release of harmful substances called Persistent Organic Pollutants (POPs) into the bloodstream. These substances can affect metabolism and muscle function, which is why the researchers want to find out if certain types of exercise, particularly eccentric muscle strengthening, can help protect against these issues better than other forms of exercise.

To be eligible for the trial, participants should be adults aged 18 to 55 who are planning to have bariatric surgery and currently do not engage in much physical activity. They should also be using effective contraception. Participants will take part in exercise sessions designed to help maintain muscle strength and function while monitoring any effects from the surgery. It's important to know that this trial is currently recruiting participants, so if you or someone you know fits the criteria and is interested, there is an opportunity to contribute to important research in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patient (18-55 years)
• • Patient scheduled for bariatric surgery
• • Patient practicing a leisure-time physical activity \< 8 hours of moderate intensity per week or \< 4 hours of high intensity per week
• • Presence of effective contraception (hormonal or mechanical)
• Exclusion Criteria:
• • Patient already involved in another experimental study
• • Pregnant (urine pregnancy test) or breast-feeding women
• • Patient in a particular situation deemed incompatible with the study by the investigator
• • Patients from outside the Alpes-Maritimes and Var departments
• • Patient having received antibiotic treatment during the 3 months preceding the first stool collection
• • Presence of a contraindication to adapted physical activity
• • Presence of a contraindication to neurostimulation