Slowing Parkinson's Early Through Exercise Dosage - United Kingdom

Launched by QUEEN MARY UNIVERSITY OF LONDON · Sep 13, 2024

Keywords

ClinConnect Summary

Slow-SPEED-UK is a randomised controlled trial investigating the effects of an app-based exercise programme in early/prodromal Parkinson's Disease (PD). The trial aims to recruit a total of 300 participants from the following cohorts: i) PD (diagnosed in previous 3 years), ii) smell loss or iii) REM-sleep behaviour disorder. Participants will be identified and recruited from a large, online, observational trial known as PREDICT-PD.

PREDICT-PD members meeting the inclusion/exclusion criteria will be contacted via email or telephone. The trial will be explained in detail, and written informa...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• In order to be eligible to participate Slow-SPEED-UK, a subject must meet the following criteria:
• 1. Either:
• Previously diagnosed with iRBD, meeting all of the following criteria, as per the International Classification of Sleep Disorders (ICSD-3):
• • 1. Repeated episodes of sleep related vocalization and/or complex motor behaviours
• • 2. These behaviours are documented by polysomnography to occur during REM sleep or, based on clinical history of dream enactment, are presumed to occur during REM sleep
• • 3. Polysomnographic recording demonstrates REM sleep without atonia (RWA)
• • 4. The disturbance is not explained more clearly by another sleep disorder, mental disorder, medication, or substance use (the usage of beta-blockers or anti-depressant as possible luxating factor is not excluded)
• OR:
• • Hyposmia, defined as olfaction less than or equal to the 15th percentile by age and sex, as determined by the University of Pennsylvania Smell Identification Test (UPSIT).
• OR:
• • Idiopathic Parkinson's disease, diagnosed by a neurologist within the previous 3 years. Subjects must be at Hoehn and Yahr stage 1-3 at baseline.
• • 2. Aged 50 years or older
• • 3. Able to understand the English language
• • 4. Able to walk independently inside the home without the use of any form of walking aid
• • 5. Less than or equal to 120 minutes of sports/outdoor activities per day (question 1-22, 30 \& 31) on LASA Physical Activity Questionnaire (LAPAQ))
• • 6. Less than an average of 10,000 steps/day during the 4-week baseline period
• • 7. In possession of a suitable smartphone (screen size minimum 4.6 inch), (Android version 9 or iOS version 15 or newer)
• Exclusion Criteria:
• • 1. Clinically diagnosed or self-reported diagnosis of a neurodegenerative disease (other than PD).
• • 2. Self-reported weekly falls in the previous 3 months
• • 3. Dexterity problems or cognitive impairments hampering smartphone use
• • 4. Subject not wishing to be informed about the association between iRBD/hyposmia and risk of future diseases
• • 5. Care home residents or hospitalised persons.
• • 6. Subject's personal smartphone is Fitbit-incompatible i.e. Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite
• • 7. Unable to give informed consent