Propofol-related Euphoria in Pain-free Gastrointestinal Endoscopy Patients

Launched by NORTHERN JIANGSU PEOPLE'S HOSPITAL · Sep 16, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the feelings of euphoria, or intense happiness, that some patients may experience after receiving propofol, a medication often used for sedation during painless gastrointestinal (GI) endoscopies. The researchers aim to understand how common this feeling is, how long it lasts, and what factors might influence it. The trial is currently looking for participants aged between 18 and 80 years old who are scheduled to have a painless GI endoscopy.

To participate, individuals must not have any history of substance abuse, certain medical conditions, or be pregnant. They also should not have taken certain medications in the past three months that could affect the study's results. If eligible, participants can expect to undergo a straightforward procedure and share their experiences afterward. This study could help improve our understanding of propofol's effects and contribute to better patient care during similar procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Proposed to perform painless GI endoscopy, and simple endoscopic maneuvers such as single small polyp clamping, performing HP examination, etc;
• • Gender is not limited;
• • 18 years old ≤ 80 years old;
• • ASA classification: I-II;
• • 18 kg/m2 \<BMI \<30 kg/m2;
• • Informed consent, voluntary participation in the trial, and informed consent signed by the subjects themselves.
• Exclusion Criteria:
• • adjudicated respiratory management difficulties;
• • History of substance abuse as well as drug use;
• • Participation in a clinical trial of another drug or device within 3 months prior to the screening period
• • Use of therapeutic drugs (e.g., benzodiazepines, opioid analgesics) by the subject within 3 months prior to the Screening Period for a variety of reasons (e.g., insomnia, pain, etc.) that may have an impact on the outcome of the trial, etc;
• • Allergy or contraindication to the study drug or components thereof;
• • Previous psychiatric or neurological disorders (e.g., schizophrenia, mania, bipolar disorder, psychosis, epilepsy, neuralgia, etc.) and a history of taking medications corresponding to the treatment of the corresponding psychiatric or neurological disorders (e.g., antidepressants, anxiolytics, convulsants, antiepileptic drugs, etc.);
• • Pregnant women;
• • Subjects with severe communication disorders due to severe hearing deterioration;
• • Refusal to participate in this study;
• • Those deemed unsuitable by the investigator.