Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

Launched by NANTES UNIVERSITY HOSPITAL · Sep 17, 2024

Keywords

ClinConnect Summary

The HOMI-LUNG study is investigating how pneumonia, specifically hospital-acquired pneumonia, affects the body in the long term, particularly concerning heart and lung diseases. The researchers want to find out how these infections may lead to worsening heart conditions and what factors contribute to these changes. They are looking for patients aged 40 and older who have either had recent heart issues, are undergoing heart surgery, have high cholesterol, or have had pneumonia and are at risk for heart disease.

Participants will share their health experiences and undergo assessments to understand the impact of pneumonia on their cardiovascular health. It's important to know that this study is currently recruiting participants, and those who join will help advance our understanding of pneumonia's effects on the heart and lungs, which could lead to better care for future patients. If you or someone you know meets the eligibility criteria, this could be a valuable opportunity to contribute to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Group A (patients with acute cardiac disease)
• • Male or female
• • Age ≥ 40years old
• • Hospitalized for acute coronary syndrome for less than 7 days.
• • Informed consent from the patient
• • Person insured under a health insurance scheme
• • Group B (patients with chronic cardiovascular disease)
• • Male or female,
• • Age ≥ 40 years old
• • Undergoing coronary artery by-pass surgery
• • Hospitalized in intensive care unit for \> 12 hours
• • Informed consent from the patient
• • Person insured under a health insurance scheme
• • Group C (patients at risk of CVRD without chronic cardiovascular disease)
• • Male or female,
• • Age ≥ 40 years old
• • Familial high levels of cholesterol or triglycerides
• • With no personal history of CVRD, with a recent negative cardiac exercise test (last test inferior to 12 months)
• • Follow-up for lipid abnormalities at high risk of CVRD events
• • Informed consent from the patient
• • Person insured under a health insurance scheme
• • Group D (patients with HAP)
• • Male or female
• • Age ≥ 40years old
• * With one or more risk factors for CVD among:
• • smoking, abnormal lipidic levels, high blood pressure, obesity, diabetes mellitus, chronic kidney disease
• • Cured from mechanically ventilated HAP during the current hospitalization
• • Informed consent from the patient or relatives
• • Person insured under a health insurance scheme
• Exclusion Criteria:
• • o Groups A, B, C and D
• • Age \>80 years old
• • Immunosuppression pre-existing to the index hospitalisation, defined as lymphopenia \< 500 elements/mm3, haematologic cancer, aplasia, chemotherapy/radiotherapy for cancer within 3 months prior to the inclusion, or anti-graft rejection drug.
• • Pregnant women, breastfeeding women.
• • Adults under guardianship or trusteeship.
• • Low probability of survival at day 28.
• • o Groups A, B, C
• • Community-acquired pneumonia or Hospital-acquired pneumonia within the last year.