The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD

Launched by ANHUI MEDICAL UNIVERSITY · Sep 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how olfactory training, which is a type of therapy designed to improve the sense of smell, can help people with Parkinson's Disease (PD) and related symptoms that are not related to movement. The goal is to see if this training can make a difference in both the sense of smell and other non-motor symptoms, like mood and cognitive functions. The trial is not yet recruiting participants, but it aims to include individuals aged 40 to 75 who have been diagnosed with Parkinson's Disease and have a lower-than-average sense of smell.

To be eligible for the trial, participants must meet certain criteria, such as having a confirmed diagnosis of Parkinson's Disease and a specific olfactory score that shows their sense of smell is weaker than what is typical for their age. They should also have stable medication plans for at least a month before joining the study. It's important to note that people with other conditions that affect smell, certain nasal issues, or significant psychiatric disorders won't be able to participate. Those who join the trial can expect to engage in olfactory training and contribute to important research that may help improve understanding and treatment of non-motor symptoms in Parkinson's Disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. PD was diagnosed according to the criteria of Movement Disorders and Parkinson Disease Group of Chinese Society of Neurology of Chinese Medical Association.
• • 2. Olfactory score was 1 standard deviation lower than the corresponding age norm;
• • 3. no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability;
• • 5.Good cooperation of patients
• Exclusion Criteria:
• • 1. Parkinson\'s syndrome and Parkinson\'s plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.;
• • 2. Neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.;
• • 3. History of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. Upper respiratory tract infection in the past 3 weeks;
• • 4. Long-term smoking and occupations that inhale chemical irritants for a long time.