Effect of Cannabis on E-Cigarette Use Behavior

Launched by JOHNS HOPKINS UNIVERSITY · Sep 20, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how using cannabis, specifically tetrahydrocannabinol (THC), affects people's behavior when using e-cigarettes. The researchers want to understand how different doses of THC might influence cravings for tobacco, feelings of motivation, heart rate, blood pressure, and even how well participants think. They will compare the effects of THC to a placebo (a substance with no active ingredients) in adults who regularly use e-cigarettes and cannabis.

To join this study, you need to be a healthy adult aged 21 or older who uses e-cigarettes daily and consumes cannabis at least once a week. Additionally, you should not be looking to quit or reduce your use of these substances in the next month. Participants will undergo some tests to confirm their use of e-cigarettes and cannabis. If you qualify and decide to join, you will participate in a lab setting where your reactions to THC and e-cigarettes will be closely monitored. It's important to note that women who can become pregnant and men with female partners should use effective contraception during the study.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • 1. Healthy non-treatment seeking adults aged 21 or older
• • 2. Report daily use of e-cigarettes
• • 3. Biological confirmation of e-cigarette use: have an expired carbon monoxide (CO) level of less than 6 ppm and a positive urine cotinine test at screening
• • 4. Report current use of cannabis (at least 1 occasion per week)
• • 5. Have experience with the inhalation route of administration for cannabis
• • 6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening.
• • 7. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contraception during the study.
• Exclusion criteria:
• • 1. Report current intention to reduce or quit cannabis or tobacco use within the next 30 days
• • 2. Meet Diagnostic and Statistical Manual (DSM-5) criteria for a substance use disorder other than alcohol, cannabis, or nicotine
• • 3. Test positive for illicit drugs other than cannabis and tobacco
• • 4. Positive breath alcohol test at study admission
• • 5. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
• • 6. Have a lifetime history of suicidal behavior (i.e. past suicide attempt), or current suicidal behavior or ideation as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS)
• • 7. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding
• • 8. Have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g., Prinzmetal's angina)
• • 9. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.