Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse

Launched by YALE UNIVERSITY · Sep 20, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Neural Mechanisms Connecting Deficient Sleep and Smoking Relapse," is designed to explore how improving sleep and emotional well-being can help adult smokers quit smoking. The researchers believe that by addressing negative feelings and enhancing self-control, they can better support people in their efforts to stop smoking. They will also look at how these changes are reflected in the brain using brain imaging techniques.

To participate in this study, you need to be between the ages of 18 and 62, have been a heavy smoker for over a year, and be able to read and understand English. You should also meet certain health criteria. However, if you are currently receiving treatment for smoking, have specific mental health issues, or are pregnant or nursing, you may not be eligible. If you join, you can expect to take part in behavioral interventions designed to help you quit, along with some assessments to track your progress. This study is not yet recruiting participants, but it aims to provide valuable insights into how sleep and emotional health can affect smoking cessation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • English literate
• • report heavy tobacco use (including nicotine e-cigarettes) for \>6 months
• • meet biochemical cut off for recent cigarette smoking or e-cigarette use
• • optimal body mass index
• Exclusion Criteria:
• • currently enrolled in other treatments
• • neuropsychiatric exclusions that could interfere with study participation, increase risk of adverse events, and/or induce deficient sleep
• • medical contraindications for fMRI, varenicline, and/or behavioral treatment
• • factors that cause deficient sleep and for which behavioral treatment has less benefit
• • women who are pregnant or nursing