Ultrasound Assessment During Weaning from Mechanical Ventilation

Launched by HOSPITAL ITALIANO DE BUENOS AIRES · Sep 19, 2024

Keywords

ClinConnect Summary

This study is a multicenter, prospective, observational trial to develop an ultrasound-based predictive model for extubation failure in mechanically ventilated ICU patients. Extubation failure, defined as re-intubation or death within 48 hours post-extubation, remains a significant challenge, occurring in 15-35% of cases. Prolonged mechanical ventilation is associated with increased morbidity, infection risk, and hospital costs. Traditional predictors, such as maximal inspiratory pressure (Pimax), rapid shallow breathing index (RSBI or Tobin index), and other clinical parameters, have shown...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (18 years or older).
• • Receiving mechanical ventilatory assistance for more than 48 hours.
• • The patient is deemed ready to undergo a Spontaneous Breathing Trial, as determined by the attending physician.
• • Ultrasound measurements are performed between 20 and 30 minutes after the initiation of the trial.
• Exclusion Criteria:
• • Patients with known or diagnosed neuromuscular disease.
• • Limitation of therapeutic effort
• • History of severe valvulopathy, severe coronary artery disease, known left ventricular ejection fraction \<35%, or known grade 3 diastolic dysfunction, or who are considered candidates for tracheostomy due to their severity.
• • History of home ventilatory support
• • Patients who do not have a good acoustic window or have any type of limitation to perform pulmonary, cardiac, or diaphragmatic ultrasound.
• • Patients who at the discretion of the treating medical team cannot be placed on a T-tube.