High-flow Nasal Oxygen Therapy for Advanced Endoscopy in High-risk Patients.

Launched by BETH ISRAEL DEACONESS MEDICAL CENTER · Sep 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether using high-flow nasal oxygen (HFNO) during certain types of endoscopy can help prevent low blood oxygen levels in patients who are at higher risk. Endoscopy is a procedure that allows doctors to look inside the stomach and intestines, but it can cause some patients to have trouble breathing while they are sedated. The researchers want to see if HFNO, which provides extra oxygen through a nasal tube, can make these procedures safer.

To participate in the trial, patients typically need to be between 65 and 74 years old and scheduled for a specific type of endoscopy that is expected to last more than 15 minutes while being under sedation. They should have certain health conditions, like sleep apnea or a higher body mass index (BMI), which can increase their risk during the procedure. Participants will be randomly assigned to either receive standard care or the HFNO treatment during their endoscopy. Throughout the procedure, the medical team will monitor their vital signs and gather feedback on how the HFNO affects patient safety and comfort. This study is currently looking for volunteers, and it's important to note that pregnant women and those with ongoing COVID-19 infections cannot participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Upper endoscopy (EGD, ERCP, EUC etc.) w/wo colonoscopy expected duration \> 15 min under MAC
• * one or more of the following:
• • Diagnosis of sleep apnea
• • BMI ≥ 30 kg/m2
• • Baseline SpO2 \< 96% or Requirement for long-term oxygen therapy
• • BOSTN score ≥ 2
• • BMI ≥ 30 kg/m2
• • Observed apnea
• • Observed loud Snoring
• • Daytime Tiredness
• • Neck circumference ≥ 16.5 inches in female, ≥ 17.5 inches in male
• Exclusion Criteria:
• • Known Pregnancy
• • Known Current infection with COVID-19
• • Planned general anesthesia