PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals

Launched by UNIVERSITY OF AARHUS · Sep 20, 2024

Keywords

ClinConnect Summary

Background

Cholestasis is defined as a decreased flow of bile from the liver to the duodenum, either due to reduced excretion from the liver, defects in the enterohepatic circulation or blockage of the biliary tree. Bile acids are essential for the absorption of lipophilic compounds from the intestine. \[1\] When bile acids accumulate in the liver, it causes damage to the tissue.

Patients with cholestasis typically present with jaundice and pruritus caused by the bile acids accumulating in the skin. Elevated blood levels of alkaline phosphatases (AP), gamma-glutamyl transferase, and somet...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Criteria for inclusion of healthy individuals
• • No prior or current history of liver diseases
• • No medication that interferes with the hepatobiliary system
• • Age above 18
• • A signed consent must be present on the day of the 11-CSAR PET/CT scan.
• • A negative pregnancy test performed on the day of the scan.
• Exclusion Criteria:
• • Prior cholecystectomy
• • Pregnancy
• • Assessed ineligibility by a medical doctor based on blood parameters measured at inclusion if these are abnormal.
• • Claustrophobia or the inability to remain still during a 45-minute scan.
• • Criteria for inclusion of patients with cholestasis
• • Cholestasis at the time of inclusion, measured by elevated AP, bilirubin, or both.
• • Ultrasound sonography which ruled out mechanical obstruction.
• • Age above 18
• • A signed consent must be present on the day of the 11C-CSAR PET/CT scan.
• • A negative pregnancy test performed on the day of the scan. Criteria for exclusion of patients with cholestasis
• • Pregnancy
• • Claustrophobia or the inability to remain still during a 45-minute scan.
• • Coagulation deficiency that does not allow hepatic vein catheter (relative).