PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy Individuals
Launched by UNIVERSITY OF AARHUS · Sep 20, 2024
Trial Information
Current as of July 24, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Background
Cholestasis is defined as a decreased flow of bile from the liver to the duodenum, either due to reduced excretion from the liver, defects in the enterohepatic circulation or blockage of the biliary tree. Bile acids are essential for the absorption of lipophilic compounds from the intestine. \[1\] When bile acids accumulate in the liver, it causes damage to the tissue.
Patients with cholestasis typically present with jaundice and pruritus caused by the bile acids accumulating in the skin. Elevated blood levels of alkaline phosphatases (AP), gamma-glutamyl transferase, and somet...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Criteria for inclusion of healthy individuals
- • No prior or current history of liver diseases
- • No medication that interferes with the hepatobiliary system
- • Age above 18
- • A signed consent must be present on the day of the 11-CSAR PET/CT scan.
- • A negative pregnancy test performed on the day of the scan.
- Exclusion Criteria:
- • Prior cholecystectomy
- • Pregnancy
- • Assessed ineligibility by a medical doctor based on blood parameters measured at inclusion if these are abnormal.
- • Claustrophobia or the inability to remain still during a 45-minute scan.
- • Criteria for inclusion of patients with cholestasis
- • Cholestasis at the time of inclusion, measured by elevated AP, bilirubin, or both.
- • Ultrasound sonography which ruled out mechanical obstruction.
- • Age above 18
- • A signed consent must be present on the day of the 11C-CSAR PET/CT scan.
- • A negative pregnancy test performed on the day of the scan. Criteria for exclusion of patients with cholestasis
- • Pregnancy
- • Claustrophobia or the inability to remain still during a 45-minute scan.
- • Coagulation deficiency that does not allow hepatic vein catheter (relative).
About University Of Aarhus
The University of Aarhus, a prestigious research institution located in Denmark, is dedicated to advancing medical science through innovative clinical trials. With a strong emphasis on interdisciplinary collaboration, the university fosters an environment that encourages cutting-edge research and the development of novel therapeutic interventions. Committed to ethical standards and patient safety, the University of Aarhus aims to contribute to the global body of medical knowledge while enhancing healthcare outcomes through rigorous scientific inquiry and evidence-based practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Aarhus, , Denmark
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported