Search / Trial NCT06611072

ACTivating the Immune Response in Ovarian CaNcer

Launched by GYNAECOLOGISCH ONCOLOGISCH CENTRUM ZUID · Sep 23, 2024

Trial Information

Current as of December 22, 2024

Not yet recruiting

Keywords

Ovarian Cancer Immune System Immune Suppression Immune System Suppression Immunotherapy Monocytes Myeloid Cells Vena Punction Bone Marrow Aspiration Spleen Biopsy Peritoneal Fluid Tumor Biopsy

ClinConnect Summary

DESCRIPTION OF THE PROBLEM

Ovarian cancer (OC) is one of the most lethal cancers due to late-stage of disease at diagnosis. Standard therapy consists of debulking surgery and chemotherapy. However, despite this aggressive treatment, recurrent disease almost invariably occurs resulting in a five-year survival rate of approximately 30%. Immunotherapy could be a way to increase survival in OC patients. However, a major barrier to a successful deployment of cancer immunotherapy for ovarian cancer patients is the immunosuppressive tumor microenvironment.

RESEARCH DIRECTION

Tumor-related infla...

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • Subjects should be at least 18 years old and mentally competent;
  • Newly diagnosed patients with OC who go for primary debulking surgery or patients with OC who are scheduled for interval debulking;
  • Controls: women who undergo surgery for benign gynaecological conditions under general anaesthesia.
  • Exclusion Criteria:
  • Mentally incompetent;
  • Pregnant or breastfeeding;
  • Known inflammatory of infectious diseases or an immunosuppressive status;
  • Using medication interfering with the immune system;
  • Severe comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas);
  • Serious psychiatric pathology;
  • A self reported alcohol consumption of \>21 units per week.

About Gynaecologisch Oncologisch Centrum Zuid

Gynaecologisch Oncologisch Centrum Zuid is a dedicated clinical trial sponsor specializing in gynecological oncology. Committed to advancing the understanding and treatment of gynecological cancers, the center conducts rigorous research and clinical trials aimed at improving patient outcomes. With a multidisciplinary team of experts, the center focuses on innovative therapies and personalized treatment approaches, ensuring the highest standards of care and ethical practices in clinical research. Through collaboration with leading institutions and adherence to regulatory guidelines, Gynaecologisch Oncologisch Centrum Zuid strives to contribute significantly to the field of oncology and enhance the quality of life for patients facing gynecological cancers.

Locations

Eindhoven, Brabant, Netherlands

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0