Search / Trial NCT06611449

The Effect of Minimal Flow Anesthesia on Oxidative and Neuroendocrine Stress Response

Launched by BEZMIALEM VAKIF UNIVERSITY · Sep 20, 2024

Trial Information

Current as of December 22, 2024

Active, not recruiting

Keywords

Low Flow Anesthesia Oxidative Stress Neuroinflammatory Response

ClinConnect Summary

General anesthesia is characterized by anesthesia, analgesia, amnesia, and muscle relaxation. The most common practice today for maintaining anesthesia after induction is to add a low-density effective inhalation anesthetic to an oxygen/air mixture. Patients who are unconscious and have stopped spontaneous breathing are actively ventilated with anesthesia machines, ensuring the anesthesia gas reaches the lungs and then the bloodstream. Minute ventilation refers to the total amount of gas (oxygen, air, and anesthetic agent mixture) a patient breathes in one minute, which is approximately 5-6...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Ages 18-65
  • Scheduled for elective septorhinoplasty
  • ASA (physical status) 1-2
  • Exclusion Criteria:
  • • ASA (physical status) III-IV
  • Under 18 or over 65
  • Pregnant individuals
  • Serious cardiovascular disease or arrhythmia
  • Chronic obstructive pulmonary disease
  • Severe respiratory failure
  • Uncontrolled cerebrovascular disease
  • Hepatic or renal dysfunction
  • Allergy to propofol, fentanyl, rocuronium, sevoflurane
  • Pituitary gland disease (e.g., pituitary adenoma)
  • Adrenal gland disease (e.g., pheochromocytoma, Cushing's disease)
  • Immune deficiency
  • Neuroendocrine system disease
  • BMI \> 40
  • Patients who refuse to provide written informed consent.

Trial Officials

Resident Doctor

Principal Investigator

Bezmialem Vakif University

About Bezmialem Vakif University

Bezmialem Vakif University is a prominent academic institution based in Istanbul, Turkey, dedicated to advancing medical research and education. As a clinical trial sponsor, the university leverages its state-of-the-art facilities and a multidisciplinary team of experts to conduct innovative research that aims to improve patient outcomes and enhance therapeutic strategies. Bezmialem Vakif University is committed to adhering to rigorous ethical standards and regulatory guidelines, ensuring the integrity and reliability of its clinical trials while fostering collaboration with global research communities. Through its initiatives, the university seeks to contribute significantly to the field of medicine and public health.

Locations

İstanbul, Fatih, Turkey

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0