Search / Trial NCT06612086

Dapagliflozin in Mangement of Patients with Pulmonary Hypertension

Launched by ASSIUT UNIVERSITY · Sep 21, 2024

Trial Information

Current as of October 09, 2024

Not yet recruiting

Keywords

Dapagliflozin Pulmonary Hypertension

Description

Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. It is clinically diagnosed by a resting mean pulmonary arterial pressure (mPAP) exceeding 20 mmHg . At present, PH\'s prevalence is approximated at 1 % of the global population and increases to 10 % for individuals over 65 years old, with considerable morbidity and mortality. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged a metabolic dysfunction and exert cardioprotective effects....

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • that the patients were diagnosed with pulmonary hypertension By Right heart cath OR suspected By Echocardiograghy according to the ESC guidelines for pulmonary hypertension that they were aged 18 years or older
  • Exclusion Criteria:
  • 1. symptomatic hypotension (systolic blood pressure \< 95 mmHg)
  • 2. impaired renal function (eGFR \< 30 mL/min/1.73 m2 calculated according to the CKD-EPI formula) and serum potassium level \> 5.2 mmol/L
  • 3. hepatic dysfunction (defined as liver parameters such as ALT, AST, and/or ALP, which are three times above the upper 99-th percentile of the reference range
  • 4. biliary cirrhosis and cholestasis, active malignancies (regardless of the stage and type of malignancy)),
  • 5. the current use of hormone replacement therapy, chemotherapy, or immunotherapy
  • 6. Type 1 diabetes mellitus
  • 7. Acute pulmonary embolism (15)
  • 8. Signficant Primary valvular Heart disease
  • 9. Ischemic heart disease

About Assiut University

Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.

Locations

Assuit, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0