Naringenin Supplementation in Bone Fracture Patients

Launched by SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES · Sep 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a natural compound called naringenin, found in grapefruit and other citrus fruits, on patients who have broken bones in their lower limbs. The researchers want to see if naringenin can help these patients heal better and faster after orthopedic surgery, as well as reduce inflammation and improve their overall quality of life. The trial aims to recruit participants who are capable of walking independently and have not undergone any major medical issues that could interfere with their recovery.

To be eligible for the study, participants must be scheduled for surgery to repair their lower limb fractures and should not have conditions like liver disease, severe kidney problems, or certain types of cancer. They also need to be able to take the naringenin capsules without any allergic reactions. If you decide to join, you will receive naringenin supplementation as part of your recovery process, and the team will monitor your progress throughout the study. This trial offers a chance to potentially enhance your healing experience after a fracture.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Candidate for orthopedic surgery for bone fractures of the lower limbs,
• • Ambulatory without assistance for a minimum of two months prior to the fracture.
• • Not having undergone amputation of the lower limbs.
• • Not suffering from liver cirrhosis.
• • Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL).
• • Not having metastatic cancer, any chronic inflammatory diseases, nor taking any drugs that affect bone metabolism, including calcitonin, bisphosphonates, and corticosteroids.
• Exclusion Criteria:
• • Allergy or intolerant reaction to narangenin capsules
• • Any abnormal changes in their liver, kidneys tests,
• • Failure to consume more than 10% of their capsules