Intravenous Acetaminophen After Cardiac Surgery - Definitive Study
Launched by MCGILL UNIVERSITY HEALTH CENTRE/RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE · Sep 23, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the use of intravenous (IV) acetaminophen, a pain relief medicine, after heart surgery to see if it can help prevent confusion (known as delirium) in patients. Researchers believe that if patients experience less pain and use fewer strong pain medications, they may have a lower chance of developing delirium in the days following their surgery. The study will compare IV acetaminophen to the usual oral acetaminophen to see which method works better for managing pain and keeping patients alert and clear-headed.
To be eligible for this trial, participants must be adults aged 18 or older who are scheduled for elective heart surgery, specifically a type of surgery called aorto-coronary bypass, with or without a valve replacement. People with certain medical conditions, those currently receiving treatment for psychiatric issues, or those who have had recent issues with alcohol, among other exclusions, will not be able to participate. If you join the trial, you can expect to receive either the IV or oral acetaminophen after your surgery and will be monitored for any effects on pain, delirium, and overall recovery for up to a year. This research aims to improve recovery experiences for heart surgery patients, making it an important study for future care.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • greater or equal to 18
- • elective cardiac surgery
- • stable pre-operative
- • aorto-coronary bypass with or without 1 valve replacement.
- Exclusion Criteria:
- • Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment
- • -
About Mcgill University Health Centre/Research Institute Of The Mcgill University Health Centre
The McGill University Health Centre (MUHC) and the Research Institute of the McGill University Health Centre (RI-MUHC) are leading institutions in clinical research and healthcare innovation. With a commitment to advancing medical knowledge and improving patient outcomes, the MUHC integrates cutting-edge research with high-quality patient care. The RI-MUHC fosters a collaborative environment where multidisciplinary teams engage in transformative research across various fields, including oncology, neurology, and cardiovascular health. By leveraging state-of-the-art facilities and a robust network of clinical expertise, both entities strive to translate scientific discoveries into effective treatments, ultimately enhancing the quality of life for patients locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Vancouver, British Columbia, Canada
Ottawa, Ontario, Canada
Winnipeg, Manitoba, Canada
Mississagua, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Quebec City, Quebec, Canada
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported