Search / Trial NCT06613256

Characterisation of Endothelial Cells in Different Inflammatory Pathologies

Launched by ROYAL SURREY COUNTY HOSPITAL NHS FOUNDATION TRUST · Sep 23, 2024

Trial Information

Current as of October 08, 2024

Recruiting

Keywords

Description

The immune system is a complex network of cells and molecules that protects the body from infection and injury. When the immune system is activated, it produces inflammation, which is a natural response to help heal the body. However, too much inflammation can be harmful and lead to serious complications, such as sepsis, low blood pressure, organ failure and death. The interaction of cells that line the blood vessels (endothelial cells, EC) with the immune system, is believed to be the root cause of these symptoms. When exposed to inflammation, the instructional molecules (RNA) inside the ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Healthy volunteer
  • * Adult ≥ 18 years
  • * Able and willing to give consent
  • Surgical patients
  • * Adult ≥ 18 years
  • * Patients admitted to RSFT for planned major surgery
  • Critically ill patients
  • * Adult ≥ 18 years
  • * Emergency admission to ICU at RSFT
  • * Meets the sepsis 3.0 definition
  • Exclusion Criteria:
  • Healthy volunteer
  • * Not currently a patient within the hospital
  • * Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD.
  • * Not on immunomodulatory medications, such as corticosteroids
  • * History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
  • Surgical patients
  • * Patients with restricted liberty, prisoners or under legal protection
  • * Anticipated prohibitively difficult venous cannulation
  • * Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, sepsis, diabetes with end organ damage, cardiovascular disease and CKD
  • * Currently prescribed immunomodulatory medication or immunocompromised
  • * Received chemotherapy within 2 weeks of predicted sampling
  • * Receiving vasopressor support prior to surgery
  • * History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
  • Critically ill patients
  • * Patients with restricted liberty, prisoners or under legal protection• Anticipated prohibitively difficult venous cannulation
  • * Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes with end organ damage, cardiovascular disease and CKD.
  • * Currently prescribed immunomodulatory medication or immunocompromised
  • * Received chemotherapy within 2 weeks of predicted sampling.
  • * History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)

About Royal Surrey County Hospital Nhs Foundation Trust

Royal Surrey County Hospital NHS Foundation Trust is a leading healthcare institution dedicated to providing high-quality clinical care and advancing medical research. As a prominent sponsor of clinical trials, the Trust is committed to enhancing patient outcomes through innovative research initiatives and collaboration with academic and industry partners. With a focus on patient safety and ethical standards, Royal Surrey County Hospital NHS Foundation Trust aims to contribute to the development of new therapies and treatment protocols, ultimately improving health care delivery in the community and beyond.

Locations

Guildford, Surrey, United Kingdom

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0