Search / Trial NCT06613321

Lung Hyperinflation and Response to Pulmonary Vasodilator Therapy

Launched by CENTRAL HOSPITAL, NANCY, FRANCE · Sep 23, 2024

Trial Information

Current as of October 08, 2024

Completed

Keywords

Copd Pulmonary Distension Lung Distension Disorders Pulmonary Hypertension Vasodilator Therapy

Description

The goal of this retrospective observational study is to evaluate if lung distension disorders can be a predictive factor of bad response to vasodilator therapy in patients with pulmonary hypertension (PH) associated with chronic obstructive pulmonary disease (COPD). The study will include all patients from the hospital, followed for PH associated with COPD under vasodilator therapy between 2015 and 2021. It will evaluate patients' lung hyperinflation according to the RV/TLC ratio and their response to treatment.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • * Patients with COPD regardless of severity defined as a FEV1/FVC ratio less than 0.70 and the presence of a risk factor (smoke exposure with at least a 10 pack-year history, or professional exposition) diagnosed with PH according to ESC/ERS 2022 classification and in whom vasodilator therapy has been initiated
  • Exclusion Criteria:
  • * other known concomitant lung disease (interstitial lung disease, cystic lung disease, mucoviscidosis...)
  • * thoracic pathology such as kyphoscoliosis
  • * pleural effusion (unless part of pulmonary veno-occlusive disease)
  • * a large tumor lung mass
  • * EFR missing or uninterpretable because difficult to perform
  • * initiation of calcium channel blockers
  • * surgical treatment in chronic thrombo-embolic pulmonary hypertension
  • * no follow-up evaluation (lost to follow-up or died before reassessment)

About Central Hospital, Nancy, France

Central Hospital, located in Nancy, France, is a leading healthcare institution dedicated to advancing medical research and improving patient outcomes. As a prominent clinical trial sponsor, the hospital is committed to conducting innovative studies across various therapeutic areas, fostering collaboration among multidisciplinary teams of healthcare professionals and researchers. With a strong emphasis on ethical standards and patient safety, Central Hospital leverages its state-of-the-art facilities and expertise to contribute to the development of cutting-edge treatments and enhance the overall quality of care within the community and beyond.

Locations

Vandoeuvre Les Nancy, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0