Microbial and Environmental Factors Associated with Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP)

Launched by HOSPICES CIVILS DE LYON · Sep 24, 2024

Keywords

ClinConnect Summary

This clinical trial, called "MicrobEnvironment in FAP," is studying how certain microbes in the gut and environmental factors may influence the development of polyps in people with Familial Adenomatous Polyposis (FAP). FAP is a genetic condition that leads to the formation of many growths, known as adenomas, in the colon and small intestine, which can turn into cancer if not treated. The trial aims to understand why some people with the same genetic mutation develop polyps more quickly than others and whether the gut bacteria play a role in this process.

To be eligible for the trial, participants must be at least 18 years old, have undergone a preventive surgery to remove the colon (called prophylactic colectomy) for at least two years, and be part of a national database for FAP patients. Additionally, they should have had regular endoscopies, which are tests to look inside the digestive tract. Participants can expect to provide stool samples and undergo evaluations to help researchers learn more about the connection between gut microbes and polyp development. It's important to note that individuals on antibiotics or probiotics shortly before the study may not be eligible. This research could provide valuable insights into managing FAP and potentially improving patient care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ≥18 years
• • Non-opposition obtained
• • Prophylactic colectomy for at least 2 years in the context of APC-related familial adenomatous polyposis with ileorectal or ileoanal anastomosis
• • Included in the national POLYPOSE database
• • Regular endoscopic follow-up with upper and lower GI endoscopy at Hôpital Edouard Herriot or Hôpital de la Croix-Rousse
• • Having performed at least 2 endoscopies as part of follow-up
• Exclusion Criteria:
• • Antibiotic therapy within 2 months prior to stool sampling
• • Taking probiotics for less than 1 month
• • Person deprived of liberty by judicial or administrative decision