Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients

Launched by TANTA UNIVERSITY · Sep 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called dexmedetomidine to see if it can help prevent confusion and memory problems, known as postoperative delirium, in older patients who have knee replacement surgery (total knee arthroplasty, or TKA). The researchers want to find out if dexmedetomidine is more effective than standard medications used during surgery. They will look at how different factors, like the patient's health and the length of the surgery, might affect outcomes.

To be eligible for this trial, patients should be older adults with severe knee arthritis who need a knee replacement and are classified as having mild to moderate health issues (grades II-III). However, those with more serious health problems or a history of conditions that could increase their risk of delirium or cognitive issues will not be included. Participants in this study can expect close monitoring during and after their surgery to see how well dexmedetomidine works in protecting their brain health during recovery. This trial is currently recruiting participants, so if you or someone you know fits the criteria, it might be a good opportunity to consider.

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Eligibility criteria

• Inclusion Criteria:
• • Patients with Severe chronic knee osteoarthritis inducing limitation of movement and required knee replacements;
• • Patients of American Society of Anesthesiologists Classification grades II-III;
• • Patients free of exclusion criteria.
• Exclusion Criteria:
• • Patients of American Society of Anesthesiologists Classification grade \>III;
• • Patients show a high risk for getting Post Operative Delirium or have severe cognitive dysfunction;
• • Patients had a history of uncompensated cardiac, renal, or hepatic diseases;
• • Patients had uncontrolled diabetes mellitus or hypertension;
• • Patients had other causes for limited movement;
• • Patients had autoimmune disease, coagulopathy, severe anemia with a hemoglobin concentration of \<7 g%;
• • Patients had local bone disorders that may prevent prosthesis stability;
• • Patients had allergies or contraindications to the study drugs.