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Search / Trial NCT06615232

The Impact of Vaginal Washing on Cervical Inflammation

Launched by UNIVERSITY OF WASHINGTON · Sep 23, 2024

Trial Information

Current as of July 02, 2025

Not yet recruiting

Keywords

Sex Work Hiv Vaginal Washing Cervicovaginal Inflammation Mucosal Barrier Disruption

ClinConnect Summary

This clinical trial is studying the effects of stopping vaginal washing on cervical inflammation and overall reproductive health in women. Vaginal washing is a practice that many women think is good for hygiene, but it might actually increase the risk of HIV and other issues. The researchers want to find out if stopping this practice can lower inflammation in the cervix and promote healthy bacteria in the vagina.

To participate in this study, women aged 18 to 50 who have washed inside their vagina in the past week and are HIV-negative may be eligible. They should not be pregnant, currently menstruating, or have certain health issues. Participants will be asked to avoid sexual activity for two weeks after undergoing a biopsy, which is a small procedure to collect tissue samples. The trial is not yet recruiting, but it aims to provide valuable information about how vaginal washing might affect women’s health.

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • Reports vaginal washing beyond the introitus in the past week
  • Female, aged 18-50
  • Presence of a cervix
  • Informed consent obtained and form signed
  • HIV-seronegative
  • Non-pregnant (urine β-hCG negative)
  • Willing to abstain from sex for 14 days after biopsy
  • Post-menarche and pre-menopause
  • Exclusion Criteria:
  • \<3 months postpartum or current breastfeeding
  • Current menstruation (can enroll after menses)
  • History of bleeding disorder
  • Visible cervical abnormality requiring evaluation
  • Medical contraindication to study protocol
  • Visible cervicovaginal ulcers or lesions
  • Positive test for gonorrhea, chlamydia, trichomonas, or wet preparation and examination findings indicating vulvovaginal candidiasis

About University Of Washington

The University of Washington (UW) is a leading academic institution renowned for its commitment to advancing healthcare through innovative research and clinical trials. With a robust network of interdisciplinary teams, UW fosters collaboration among top-tier researchers, clinicians, and healthcare professionals, aiming to translate scientific discoveries into impactful treatments and interventions. The university is dedicated to ethical research practices and participant safety, ensuring rigorous adherence to regulatory standards in all clinical trials. Through its state-of-the-art facilities and extensive expertise, UW strives to address pressing health challenges and improve patient outcomes on a local and global scale.

Locations

Patients applied

0 patients applied

Trial Officials

Michelle Sabo, Md, PhD

Principal Investigator

University of Washington

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported