Search / Trial NCT06615622

Our Study Aims to Determine If Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and If This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.

Launched by ASSIUT UNIVERSITY · Sep 25, 2024

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Trial Information

Current as of December 21, 2024

Recruiting

Keywords

Peripheral Nerve Ultrasound Immune Mediated Nerve Disorders Guillain Barré Syndrome Chronic Inflammatory Demyelinating Polyradiculoneuropathy

ClinConnect Summary

This clinical trial is investigating how ultrasound can help detect changes in nerves for people with Guillain-Barré Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). These conditions affect the peripheral nerves, which are essential for communication between the brain and the rest of the body. The researchers want to see if the findings from ultrasound match results from other tests, which could lead to earlier diagnoses and better treatment options. By looking at nerve changes over time, the study aims to understand how these conditions progress and whether they differ between types of nerve damage.

To participate, you need to be between 18 and 75 years old and have a confirmed diagnosis of GBS or CIDP. If you have recently started experiencing symptoms of GBS or have a relapsing or progressive form of CIDP, you might be eligible. If you join the study, you will undergo a series of tests, including ultrasound examinations of your nerves. Researchers hope that this study will improve how doctors diagnose and treat these conditions, ultimately helping patients achieve better outcomes.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Diagnosis of patient group:
  • • GBS Patients: Diagnosed according to the criteria of the National Institute of Neurological Disorders and Stroke (NINDS) and the Brighton Collaboration (2011).
  • • CIDP Patients: Diagnosed according to the criteria of the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS).
  • • 2. Age: Participants aged 18 to 75 years.
  • 3. Onset:
  • • GBS Patients: Recent onset of GBS within the first 2 weeks of symptom onset.
  • • CIDP Patients: Either relapsing or progressive course consistent with CIDP diagnosis.
  • • 4. Gender: Both male and female participants are eligible.
  • • 5. Participation: Willingness to participate in the study, including undergoing disease-related examinations and assessments.
  • • 6. Consent: Ability and willingness to provide informed consent
  • Exclusion Criteria:
  • • 1. Patients unable or unwilling to provide informed consent.
  • • 2. Patients with metabolic disorders or malignancies.
  • • 3. Patients with other causes of peripheral neuropathy.
  • • 4. Patients with other causes of acute flaccid paralysis.

About Assiut University

Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.

Locations

Assiut, , Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0