Search / Trial NCT06615726

Regular Physical Activity in Patients with Symptomatic Intracranial Arterial Stenosis

Launched by CAPITAL MEDICAL UNIVERSITY · Sep 24, 2024

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Trial Information

Current as of October 09, 2024

Recruiting

Keywords

Ischemic Stroke Transient Ischemic Attack Symptomatic Intracranial Arterial Stenosis

Description

The intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and the result of increasing global burden of stroke. There are significant racial differences in the incidence of ICAS, which account for 8%-10% of stroke causes in North America and 30%-50% in Asia. In China, the incidence of ICAS in patients with ischemic stroke or transient ischemic attack (TIA) is as high as 46.6%. Previous studies have shown that stroke patients with ICAS have more severe symptoms, longer hospital stay and higher stroke recurrence rate, and the recurrence rate of stroke increases wi...

Gender

ALL

Eligibility criteria

  • 1. Inclusion criteria:
  • 1. Age ≥40 years and ≤80 years;
  • 2. Ischemic stroke or TIA (transient ischemic attack) onset ≤30 days;
  • 3. Ischemic stroke or TIA is attributed to 50-99% of the ICAS (internal carotid artery, M1 segment of middle cerebral artery, basilar artery, vertebral artery; the degree of stenosis is determined by magnetic resonance angiography, computed tomography angiography, digital subtraction angiography using the standards of warfarin-aspirin symptomatic intracranial disease );
  • 4. mRS (modified Rankin Scale)≤4;
  • 5. The patient himself or his legal representative signs the informed consent form.
  • 2. Exclusion criteria:
  • 1. Stroke progression within the past 3 days (defined as an increase in the score of National Institute of Health Stroke Scale ≥4 points or an increase in individual items of ≥2 points).
  • 2. mRS≥1 before the stroke onset.
  • 3. Concurrent osteoarthritis, fracture, lower limb venous thrombosis, unstable angina pectoris, respiratory diseases, limb disabilities, etc., making it theoretically difficult to cooperate with the physical activity plan for this trial.
  • 4. Complicated with motor disorders such as Parkinson\'s disease and Parkinson\'s syndrome.
  • 5. The vessels responsible for this stroke had tandem lesions (more than 50% of extracranial artery stenosis).
  • 6. The vessel responsible for this stroke has undergone intracranial balloon angioplasty and/or stent implantation (except for mechanical thrombectomy and/or aspiration alone).
  • 7. It is expected that intracranial arterial balloon angioplasty and/or stent implantation will be performed on the vessel responsible for the stroke within 3 months.
  • 8. Patients who exercised regularly within the last 6 months. Regular exercise is defined as four or more moderate intensity exercises per week for more than 10 minutes each time or two or more high intensity exercises per week for more than 10 minutes each time.
  • 9. Inability to understand and/or comply with the trial procedures and/or follow-up due to mental illness, cognitive or emotional disorders.
  • 10. Life expectancy is less than one year.
  • 11. Women who are known to be pregnant or nursing, or have a positive pregnancy test;
  • 12. Are participating in other drug or device research.
  • 13. There are other circumstances that investigators consider are not suitable for enrollment.

About Capital Medical University

Capital Medical University is a leading institution in medical education and research, dedicated to advancing healthcare through innovative clinical trials. With a strong emphasis on scientific rigor and ethical standards, the university collaborates with a network of healthcare professionals and researchers to drive breakthroughs in medical science. Capital Medical University aims to enhance patient care and improve health outcomes by fostering a multidisciplinary approach to clinical research, ensuring that its trials are designed to address critical health challenges and contribute valuable insights to the medical community.

Locations

Beijing, Beijing, China

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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