Regular Physical Activity in Patients With Symptomatic Intracranial Arterial Stenosis
Launched by CAPITAL MEDICAL UNIVERSITY · Sep 24, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether regular physical activity can help prevent strokes in patients who have symptoms from a narrowing of the arteries in the brain, known as symptomatic intracranial arterial stenosis. The trial is currently recruiting participants aged between 40 and 80 years who have experienced an ischemic stroke or a transient ischemic attack (TIA) within the last 30 days. To be eligible, individuals must have a certain degree of artery narrowing and be able to understand and consent to participate in the study.
Participants in this trial can expect to engage in a structured physical activity program designed to improve their health and reduce the risk of future strokes. It’s important to note that those who have had significant recent strokes, certain medical conditions, or have been exercising regularly in the past six months may not qualify for the study. Overall, the trial aims to find out if staying active can be a safe and effective way to help patients with this specific condition.
Gender
ALL
Eligibility criteria
- 1. Inclusion criteria:
- • 1. Age ≥40 years and ≤80 years;
- • 2. Ischemic stroke or TIA (transient ischemic attack) onset ≤30 days;
- • 3. Ischemic stroke or TIA is attributed to 50-99% of the ICAS (internal carotid artery, M1 segment of middle cerebral artery, M2 segment of middle cerebral artery, basilar artery, or vertebral artery; the degree of stenosis is determined by magnetic resonance angiography, computed tomography angiography, digital subtraction angiography using the standards of warfarin-aspirin symptomatic intracranial disease );
- • 4. mRS (modified Rankin Scale)≤4;
- • 5. The patient himself or his legal representative signs the informed consent form.
- 2. Exclusion criteria:
- • 1. Stroke progression within the past 3 days (defined as an increase in the score of National Institute of Health Stroke Scale ≥4 points or an increase in individual items of ≥2 points).
- • 2. mRS≥1 before the stroke onset.
- • 3. Concurrent osteoarthritis, fracture, lower limb venous thrombosis, unstable angina pectoris, respiratory diseases, limb disabilities, etc., making it theoretically difficult to cooperate with the physical activity plan for this trial.
- • 4. Complicated with motor disorders such as Parkinson\'s disease and Parkinson\'s syndrome.
- • 5. The vessels responsible for this stroke had tandem lesions (more than 50% of extracranial artery stenosis).
- • 6. The vessel responsible for this stroke has undergone intracranial balloon angioplasty and/or stent implantation (except for mechanical thrombectomy and/or aspiration alone).
- • 7. It is expected that intracranial arterial balloon angioplasty and/or stent implantation will be performed on the vessel responsible for the stroke within 3 months.
- • 8. Patients who exercised regularly within the last 6 months. Regular exercise is defined as four or more moderate intensity exercises per week for more than 10 minutes each time or two or more high intensity exercises per week for more than 10 minutes each time.
- • 9. Inability to understand and/or comply with the trial procedures and/or follow-up due to mental illness, cognitive or emotional disorders.
- • 10. Life expectancy is less than one year.
- • 11. Women who are known to be pregnant or nursing, or have a positive pregnancy test;
- • 12. Are participating in other drug or device research.
- • 13. There are other circumstances that investigators consider are not suitable for enrollment.
About Capital Medical University
Capital Medical University is a leading institution in medical education and research, dedicated to advancing healthcare through innovative clinical trials. With a strong emphasis on scientific rigor and ethical standards, the university collaborates with a network of healthcare professionals and researchers to drive breakthroughs in medical science. Capital Medical University aims to enhance patient care and improve health outcomes by fostering a multidisciplinary approach to clinical research, ensuring that its trials are designed to address critical health challenges and contribute valuable insights to the medical community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Zhengzhou, Henan, China
Beijing, Beijing, China
Zhengzhou, Henan, China
Wuhu, Anhui, China
Xinxiang, Henan, China
Xiangtan, Hunan, China
Shangqiu, Henan, China
Dongying, Shandong, China
Liaocheng, Shandong, China
Nanyang, Henan, China
Zhengzhou, Henan, China
Tangshan, Hebei, China
Jilin, Jilin, China
Zhengzhou, Henan, China
Zhoukou, Henan, China
Shangqiu, Henan, China
Suzhou, Anhui, China
Shihezi, Xinjiang, China
Liuyang, Hunan, China
Fuyang, Anhui, China
Huainan, Anhui, China
Beijing, Beijing, China
Chongqing, Chongqing, China
Heyuan, Guangdong, China
Guizhou, Guiyang, China
Xingtai, Hebei, China
Kaifeng, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Shenyang, Liaoning, China
Tongliao, Neimenggu, China
Jinan, Shandong, China
Rizhao, Shandong, China
Weifang, Shandong, China
Dezhou, Shangdong, China
Yantai, Shan, China
Chengdu, Sichuan, China
Wenzhou, Zhejiang, China
Wenzhou, Zhejiang, China
Zhangzhou, Fujian, China
Foshan, Guangdong, China
Foshan, Guangdong, China
Guangzhou, Guangdong, China
Cangzhou, Hebei, China
Shijiazhuang, Hebei, China
Gongyi, Henan, China
Nan, Henan, China
Lichuan, Hubei, China
Yueyang, Hubei, China
T, H, China
Jiujiang, Jiangxi, China
Dezhou, Shandong, China
Laixi, Shandong, China
Yantai, Shandong, China
Zaozhuang, Shandong, China
Shanghai, Shanghai, China
Jianyang, Sichuan, China
Ya 'An, Sichuan, China
Nanyang, Henan, China
Yaan, Sichuan, China
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported