Topical 10% Povidone-Iodine in Preventing White Spots

Launched by UNIVERSITY OF WASHINGTON · Sep 24, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of a topical treatment called 10% Povidone-Iodine (Povi-One) in preventing white spot lesions on the front teeth of healthy children and teens aged 10 to 17 who are starting orthodontic treatment. White spot lesions are early signs of tooth decay that can appear during braces treatment. Researchers will compare Povi-One to a placebo (a treatment that looks the same but doesn’t have any active ingredients) to see if it helps reduce the development of these spots over one year.

To participate, candidates must be healthy, have at least four permanent front teeth, and be expected to wear braces for at least a year. Those with allergies to iodine, certain health conditions, or who are pregnant cannot join. Participants will receive Povi-One or the placebo at several visits, and their teeth will be checked regularly to observe any changes. The trial aims to ensure the treatment is safe and effective, and caregivers will be asked about any side effects during the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy children and teens (10-17 years old)
• • Transitional or permanent dentition of at least 4 permanent anterior teeth in each arch
• • Full fixed appliance orthodontic treatment is expected to last at least one year
• Exclusion Criteria:
• • Allergies to iodine
• • Chronic prophylactic use of antibiotics
• • Diagnosis of thyroid disease
• • Conditions that could impair routine oral hygiene procedures.
• • Pregnant at enrollment