Search / Trial NCT06616259

First-line Treatment of MCapOX + Cetuximab Vs. MFOLFOX6 + Cetuximab for RAS/BRAF Wild-type, MSS, Unresectable Left-Sided MCRC: a Multicenter, Randomized, Controlled, Phase III Study

Launched by MENG QIU · Sep 24, 2024

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Trial Information

Current as of December 22, 2024

Not yet recruiting

Keywords

Capcet Iii

ClinConnect Summary

Study participants who meet the enrollment criteria will be randomly assigned in a 1:1 ratio to either the mCapOX + cetuximab or mFOLFOX6 + cetuximab treatment groups, and those who have achieved control of their disease (Complete response \[CR\] + Partial response \[PR\] + Stable disease \[SD\]) after a maximum of 12 cycles of first-line induction therapy in both groups will continue to receive Capecitabine or Capecitabine + Cetuximab maintenance therapy until disease progression or toxicity is not tolerated or informed consent is withdrawn.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Able to provide written informed consent and can understand and comply with the requirements of the study.
  • • Men and women ≥ 18 years of age.
  • • Patients with histologically or cytologically confirmed RAS and BRAF wild-type, MSS/pMMR, metastatic left-sided colorectal adenocarcinoma.
  • • Presence of at least one evaluable lesion, as defined in RECIST Version 1.1.
  • • With an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
  • • No palliative first-line chemotherapy, targeted, immunotherapy, or prior platinum-based adjuvant chemotherapy, relapse more than 12 months from the end of adjuvant chemotherapy.
  • • According to the imaging findings and surgical assessment of initial unresectable, synchronous metastatic colorectal cancer, no serious complications of the primary tumor (obstruction, perforation, massive hemorrhage that cannot be treated in internal medicine, etc.) .
  • • Requirements for lab indicators: neutrophils ≥ 1.5 × 10\^9/L, platelets ≥ 75 × 10\^9/L, hemoglobin ≥ 8 g/dL; total bilirubin ≤ 1.5 × upper limit of normal (UNL); ASAT (SGOT) and/or ALAT (SGPT) ≤ 2.5 × UNL (≤ 5 × UNL if liver metastases); alkaline phosphatase ≤ 2.5 × UNL (≤ 5 × UNL if liver metastases, ≤ 10 × UNL if bone metastases); LDH \< 1500 U/L; creatinine clearance (calculated according to Cockcroft and Gault formula) \> 50 mL/min or serum creatinine ≤ 1.5 × UNL.
  • Exclusion Criteria:
  • • Patients with mCRC who were initially resectable with R0 resection or radiofrequency or SBRT were excluded.
  • • Patients diagnosed with MSI-H or dMMR by PCR or immunohistochemistry
  • • Hypersensitivity to any therapeutic agent.
  • • Patients who received adjuvant chemotherapy containing oxaliplatin and fluorouracil within 12 months before entering the study.
  • • Patients who have failed one or more palliative chemotherapy regimens.
  • • Patients with uncontrolled hepatitis B virus.
  • • Peripheral neuropathy ≥ CTC grade 2.
  • • Neurological or psychiatric disorders affecting cognitive performance.
  • • Patients with central nervous system metastasis could not be controlled with radiotherapy.
  • • Previous enteritis, chronic diarrhea, or recurrent bowel obstruction; uncontrolled bleeding from internal medicine; bowel perforation.
  • • Uncontrolled concomitant diseases within 6 months before the study, including unstable angina, acute myocardial infarction, cerebrovascular accident, etc.
  • • Pregnant or lactating patients, or those of childbearing potential who do not take adequate contraceptive measures.
  • • History of other malignancies, but no disease-free survival longer than 5 years.
  • • Patients concurrently receiving other anti-tumor treatment or participating in other interventional clinical trials.
  • • Patients who are unable to comply with this study for psychological, family or social reasons.
  • • Patients with other serious diseases that the investigator considers not suitable.

About Meng Qiu

Meng Qiu is a forward-thinking clinical trial sponsor dedicated to advancing medical research and innovation. With a focus on developing novel therapies and enhancing patient care, Meng Qiu collaborates with healthcare professionals and research organizations to design and conduct rigorous clinical trials. The organization prioritizes ethical standards, patient safety, and scientific integrity, aiming to deliver impactful solutions that address unmet medical needs. Through its commitment to excellence and collaboration, Meng Qiu strives to contribute to the global healthcare landscape and improve outcomes for patients worldwide.

Locations

Chengdu, Sichuan, China

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0