Dexamethasone Phonophoresis Versus Laser Acupuncture on Chronic Rhinosinusitis

Launched by CAIRO UNIVERSITY · Sep 25, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring whether two extra treatments added to usual care can help people with chronic rhinosinusitis (long-lasting sinus problems) more than standard medicine alone. In Cairo, Egypt, adults aged 30–50 with CRS for at least 12 weeks and at least two symptoms (like nasal drainage, nasal blockage, facial pain, or reduced sense of smell) can join. Participants are randomly put into one of three groups: Group A gets dexamethasone delivered through the skin using ultrasound (phonophoresis) along with usual meds; Group B gets low‑level laser therapy at specific acupuncture points along with usual meds; Group C receives usual meds only. The goal is to compare these approaches to see which helps most.

Participants will have about three treatment sessions per week for four weeks. The main results are checked about one month after starting: a SNOT-22 questionnaire, which asks about how sinus problems affect daily life, and a CT scan to look for changes in sinus mucosal swelling. The study is still enrolling and results aren’t available yet. It is led by Cairo University, with safety oversight, and plans to enroll around 90 people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age range between 30 to 50 years.
• • Male and female patients will participate in the study.
• * All patients have chronic rhinosinusitis, who are experiencing 12 weeks or longer of 2 or more of the following signs and symptoms:
• • mucopurulent drainage (anterior, posterior, or both) nasal obstruction (congestion) facial pain-pressure-fullness, or decreased sense of smell
• • • All patients enrolled in the study will have their informed consent.
• Exclusion Criteria:
• • Patients with metal implants (pacemakers, dental implants, or any other implants).
• • Patients with cancer, pregnancy or impaired vascular circulation.
• • Patients who suffer from mental or psychological disorders.
• • Patients with any systemic diseases that may interfere with the objectives of the study.
• • Patients with long-term use of corticosteroids or immunosuppressive agents.
• • Congenital defects on face and nose.
• • Fracture of nose or face.
• • Patients who are contraindicated for corticosteroids use in patient who will receive dexamethasone phonophoresis.
• • Allergic patients.
• • Pervious nasal surgery.
• • Patients with nasal septum deviation.
• • patients who had used antihistamines within 1 week, topical corticosteroids within2 weeks, systemic corticosteroids within 4 weeks, anti-cholinergic drugs within 3 days, antileukotriene drugs within 1 week, decongestants within 3 days, tricyclic antidepressants or phenothiazines within 2 weeks, non-steroidal analgesics within 2 weeks or any medication that may interfere with the objectives of the study.