Search / Trial NCT06616870

Study of the Predictive and Prognostic Role of Pharmacogenetic and Radiogenic Variants on the Response to Neoadjuvant Chemoradiation Therapy in Patients With Locally Advanced Rectal Cancer

Launched by CENTRO DI RIFERIMENTO ONCOLOGICO - AVIANO · Sep 25, 2024

Trial Information

Current as of October 08, 2024

Not yet recruiting

Keywords

Description

No description provided

Gender

ALL

Eligibility criteria

  • Eligibility criteria:
  • 1. histologically confirmed diagnosis of primary resectable LARC;
  • 2. confirmed absence of distant metastases;
  • 3. ≥18 years old;
  • 4. stage of disease T3-T4 and N0-N2;
  • 5. performance status (World Health Organisation) 0-2;
  • 6. normal bone marrow, kidney and liver function;
  • Exclusion Criteria:
  • 1. evidence of secondary tumour
  • 2. inadequate liver function (bilirubin \>1.5 times the normal range, ALT and AST \>2 times the normal range);
  • 3. inadequate renal function (creatinine \>1.5 times the upper limit of normal range);
  • 4. Major concomitant systemic diseases that contraindicate surgery;
  • 5. significant cardiovascular disease (heart failure, acute myocardial infarction within the last year, active angina, cardiac arrhythmia to be treated, uncontrolled hypertension)
  • 6. systemic disease contraindicating radiotherapy

About Centro Di Riferimento Oncologico Aviano

Centro di Riferimento Oncologico - Aviano is a leading cancer research and treatment center in Italy, dedicated to advancing oncology through innovative clinical trials and comprehensive patient care. As a prominent institution in the field, it specializes in the development of new therapies and diagnostic approaches, leveraging a multidisciplinary team of experts to enhance treatment outcomes. The center actively collaborates with national and international research networks, fostering a commitment to improving cancer care and contributing to the global understanding of oncology through rigorous scientific inquiry.

Locations

Aviano, Pordenone, Italy

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0