Search / Trial NCT06617078

Benefit of High-flow Nasal Cannula on Persistent Dyspnea in Ild

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Sep 26, 2024

Trial Information

Current as of December 22, 2024

Not yet recruiting

Keywords

Chronic Breathlessness Ild High Nasal Flow Canula

ClinConnect Summary

The study will be a non-blinded, two-arm, crossover (2 periods of 2 weeks each), randomised controlled superiority multicentre trial comparing the effect of HFNT on persistent dyspnoea in intersititial lung disease patients with chronic respiratory failure as compared to LTOT over a two-week period. The oxygen flow rate with HFNT will be the same as for usual care. The HFNT will be used during the night and during the 3-minute chair rise test, it can be used during the day depending on the patient's needs. During the rest of the time, the LTOT will be used as in usual care. Participants wil...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Intertitial lung disease
  • Persistant dyspnea (mMRC≥3)
  • Long-term oxygen therapy at least for 3 months
  • Exclusion Criteria:
  • Chronic respiratory disease (COPD, lung cancer)
  • Pneumothorax,
  • Pneumomediastinum,
  • Active smoker,
  • Patient on non-invasive ventilation or continuous positive airway pressure (CPAP),
  • Pregnancy or breastfeeding,
  • Unable to read or understand questionnaires,
  • No written consent,
  • Patients under guardianship,
  • No health assurance coverage

Trial Officials

Capucine Morélot-Panzini, MD,PhD, Prof

Principal Investigator

APHP • Assistance Publique des hôpitaux de Paris

About Assistance Publique Hôpitaux De Paris

Assistance Publique - Hôpitaux de Paris (AP-HP) is a leading public hospital system in France, renowned for its commitment to healthcare excellence and innovative medical research. As a prominent clinical trial sponsor, AP-HP plays a pivotal role in advancing medical knowledge and improving patient care through rigorous scientific investigations across a wide range of therapeutic areas. With a focus on collaboration and interdisciplinary approaches, AP-HP leverages its extensive network of hospitals and expert clinicians to facilitate high-quality clinical trials that adhere to the highest ethical and regulatory standards, ultimately aiming to translate research findings into tangible health benefits for diverse patient populations.

Locations

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0